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MAK21 RNA-binding ribosome biosynthesis protein MAK21 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851632, updated on 2-Nov-2024

Summary

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Official Symbol
MAK21
Official Full Name
RNA-binding ribosome biosynthesis protein MAK21
Primary source
SGD:S000002467
Locus tag
YDR060W
See related
AllianceGenome:SGD:S000002467; FungiDB:YDR060W; VEuPathDB:YDR060W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NOC1
Summary
Enables mRNA binding activity. Involved in ribosomal large subunit assembly. Located in nucleolus. Part of Noc1p-Noc2p complex. Orthologous to human CEBPZ (CCAAT enhancer binding protein zeta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MAK21 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (570649..573726)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Asp Neighboring gene E2 ubiquitin-conjugating protein UBC5 Neighboring gene uncharacterized protein Neighboring gene serine C-palmitoyltransferase LCB2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The origin of nucleus: rebuild from the prokaryotic ancestors of ribosome export factors. Ohyanagi H, et al. Gene, 2008 Nov 1. PMID 18620034
  2. Mak21p of Saccharomyces cerevisiae, a homolog of human CAATT-binding protein, is essential for 60 S ribosomal subunit biogenesis. Edskes HK, et al. J Biol Chem, 1998 Oct 30. PMID 9786894
  3. Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Milkereit P, et al. Cell, 2001 May 18. PMID 11371346
  4. The Noc-domain containing C-terminus of Noc4p mediates both formation of the Noc4p-Nop14p submodule and its incorporation into the SSU processome. Kühn H, et al. PLoS One, 2009 Dec 18. PMID 20019888, Free PMC Article
  5. Rrp5 establishes a checkpoint for 60S assembly during 40S maturation. Khoshnevis S, et al. RNA, 2019 Sep. PMID 31217256, Free PMC Article

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mRNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Noc1p-Noc2p complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RNA-binding ribosome biosynthesis protein MAK21
NP_010345.3
  • Constituent of 66S pre-ribosomal particles; required for large (60S) ribosomal subunit biogenesis; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    570649..573726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180368.3 → NP_010345.3  TPA: RNA-binding ribosome biosynthesis protein MAK21 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010345.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS46, Q12176
    UniProtKB/TrEMBL
    A6ZY25, C7GVS6, C8Z4X9
    Conserved Domains (1) summary
    COG5593
    Location:173 → 1022
    COG5593; Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12176.1

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