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PAA1 polyamine acetyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851643, updated on 18-Sep-2024

Summary

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Official Symbol
PAA1
Official Full Name
polyamine acetyltransferase
Primary source
SGD:S000002478
Locus tag
YDR071C
See related
AllianceGenome:SGD:S000002478; FungiDB:YDR071C; VEuPathDB:YDR071C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables aralkylamine N-acetyltransferase activity and diamine N-acetyltransferase activity. Involved in chromatin organization. Located in cytoplasm. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Orthologous to human AANAT (aralkylamine N-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PAA1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (588827..589402, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ubiquitin-specific protease DOA4 Neighboring gene Fmp16p Neighboring gene inositolphosphotransferase Neighboring gene Snf11p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deciphering the melatonin metabolism in Saccharomyces cerevisiae by the bioconversion of related metabolites. Muñiz-Calvo S, et al. J Pineal Res, 2019 Apr. PMID 30633359
  2. Characterization of the Saccharomyces cerevisiae homolog of the melatonin rhythm enzyme arylalkylamine N-acetyltransferase (EC 2.3.1.87). Ganguly S, et al. J Biol Chem, 2001 Dec 14. PMID 11559708
  3. A yeast polyamine acetyltransferase. Liu B, et al. J Biol Chem, 2005 Apr 29. PMID 15723835
  4. Finding pathway-modulating genes from a novel Ontology Fingerprint-derived gene network. Qin T, et al. Nucleic Acids Res, 2014 Oct. PMID 25063300, Free PMC Article
  5. Distinct SUMO ligases cooperate with Esc2 and Slx5 to suppress duplication-mediated genome rearrangements. Albuquerque CP, et al. PLoS Genet, 2013. PMID 23935535, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables aralkylamine N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aralkylamine N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diamine N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diamine N-acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polyamine acetyltransferase
NP_010356.1
  • Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    588827..589402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180379.1 → NP_010356.1  TPA: polyamine acetyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010356.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS57, Q12447
    UniProtKB/TrEMBL
    A6ZY36, B3LGJ9, B5VFW8, C7GVR5, C8Z4Y9, G2WAH5, N1P685
    Conserved Domains (1) summary
    COG0456
    Location:11 → 184
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12447.1

Gene LinkOut

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