IPT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: IPT1
Primary source: FungiDB:YDR072C
Locus tag: YDR072C
See related: SGD:S000002479; AllianceGenome:SGD:S000002479; VEuPathDB:YDR072C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: KTI6; MIC2; SYR4
Summary: Enables transferase activity, transferring phosphorus-containing groups. Involved in mannosyl diphosphorylinositol ceramide metabolic process; negative regulation of autophagy; and sphingolipid biosynthetic process. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (589761..591344, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data point to a negative regulation of autophagy by both Ipt1 and Skn1 in yeast, with a putative involvement of phytosphingosine in this process.
Title: Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae.
KTI6 encodes a factor needed for Kluyveromyces lactis zymocin, a trimeric (alphabetagamma) protein toxin complex, entry into the Saccharomyces cerevisiae cell.
Title: Mannosyl-diinositolphospho-ceramide, the major yeast plasma membrane sphingolipid, governs toxicity of Kluyveromyces lactis zymocin.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables inositol phosphoceramide synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring phosphorus-containing groups	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in inositol phosphoceramide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in mannosyl diphosphorylinositol ceramide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of autophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
part_of inositol phosphoceramide synthase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: inositolphosphotransferase

NP_010357.3

EC 2.7.1.228

Inositolphosphotransferase; involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

589761..591344 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180380.3 → NP_010357.3 TPA: inositolphosphotransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010357.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VS58, P38954

UniProtKB/TrEMBL

C8Z4Z0, N1P4M2

Conserved Domains (1) summary

cd03386
Location:162 → 316

PAP2_Aur1_like; PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin.