IPT1 inositolphosphotransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: IPT1
Official Full Name: inositolphosphotransferase
Primary source: SGD:S000002479
Locus tag: YDR072C
See related: AllianceGenome:SGD:S000002479; FungiDB:YDR072C; VEuPathDB:YDR072C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: KTI6; MIC2; SYR4
Summary: Enables transferase activity, transferring phosphorus-containing groups. Involved in mannosyl diphosphorylinositol ceramide metabolic process; negative regulation of autophagy; and sphingolipid biosynthetic process. Located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See IPT1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (589761..591344, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data point to a negative regulation of autophagy by both Ipt1 and Skn1 in yeast, with a putative involvement of phytosphingosine in this process.
Title: Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae.
KTI6 encodes a factor needed for Kluyveromyces lactis zymocin, a trimeric (alphabetagamma) protein toxin complex, entry into the Saccharomyces cerevisiae cell.
Title: Mannosyl-diinositolphospho-ceramide, the major yeast plasma membrane sphingolipid, governs toxicity of Kluyveromyces lactis zymocin.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring phosphorus-containing groups	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mannosyl diphosphorylinositol ceramide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in mannosyl diphosphorylinositol ceramide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of autophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
part_of inositol phosphoceramide synthase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: inositolphosphotransferase

NP_010357.3

EC 2.7.1.228

Inositolphosphotransferase; involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

589761..591344 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180380.3 → NP_010357.3 TPA: inositolphosphotransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010357.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VS58, P38954

UniProtKB/TrEMBL

C8Z4Z0, N1P4M2

Conserved Domains (1) summary

cd03386
Location:162 → 316

PAP2_Aur1_like; PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin.