RAD55 putative DNA-dependent ATPase RAD55 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: RAD55
Official Full Name: putative DNA-dependent ATPase RAD55
Primary source: SGD:S000002483
Locus tag: YDR076W
See related: AllianceGenome:SGD:S000002483; FungiDB:YDR076W; VEuPathDB:YDR076W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable ATP-dependent activity, acting on DNA. Predicted to contribute to crossover junction DNA endonuclease activity and four-way junction DNA binding activity. Involved in heteroduplex formation and meiotic DNA recombinase assembly. Part of Rad51C-XRCC3 complex. [provided by Alliance of Genome Resources, Oct 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See RAD55 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (598468..599688)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Role of the Rad55-Rad57 Complex in DNA Repair.
Title: The Role of the Rad55-Rad57 Complex in DNA Repair.
The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.
Title: The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.
The data suggest a model in which Csm2-Psy3 recruit the Shu complex to homologous recombination substrates, where it interacts with Rad51 through Rad55-Rad57 to stimulate Rad51 filament assembly and stability, promoting error-free repair.
Title: The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination.
The Rad55-Rad57 heterodimer appears to have a unique function in spontaneous recombination that is not essential for DSB repair.
Title: Suppression of the double-strand-break-repair defect of the Saccharomyces cerevisiae rad57 mutant.
Rad55 and Rad57 have different roles in the recombinational repair of stalled replication forks compared with double-strand break repair.
Title: Role of the Saccharomyces cerevisiae Rad51 paralogs in sister chromatid recombination.
Rad51-independent allelic conversion and break-induced replication occur independently of Rad55, Rad57, and Dmc1 but require Rad52.
Title: Rad51-independent interchromosomal double-strand break repair by gene conversion requires Rad52 but not Rad55, Rad57, or Dmc1.
These results suggest that Rad55-S2,8,14 phosphorylation activates recombinational repair, allowing for faster recovery after genotoxic stress.
Title: Phosphorylation of Rad55 on serines 2, 8, and 14 is required for efficient homologous recombination in the recovery of stalled replication forks.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to crossover junction DNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to four-way junction DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA recombinase assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in heteroduplex formation	IDA Inferred from Direct Assay more info	PubMed
involved_in meiosis I cell cycle process	IEA Inferred from Electronic Annotation more info
involved_in meiotic DNA recombinase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic DNA recombinase assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rad51C-XRCC3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rad51C-XRCC3 complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in replication fork	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: putative DNA-dependent ATPase RAD55

NP_010361.3

Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

598468..599688

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180384.3 → NP_010361.3 TPA: putative DNA-dependent ATPase RAD55 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010361.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VS62, P38953

UniProtKB/TrEMBL

B3LGJ4, C7GVR1, C8Z4Z4, N1P688

Conserved Domains (1) summary

COG0467
Location:15 → 321

RAD55; RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms]