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PDC2 Pdc2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851654, updated on 28-Oct-2024

Summary

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Official Symbol
PDC2
Official Full Name
Pdc2p
Primary source
SGD:S000002488
Locus tag
YDR081C
See related
AllianceGenome:SGD:S000002488; FungiDB:YDR081C; VEuPathDB:YDR081C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of glycolytic fermentation to ethanol; positive regulation of thiamine biosynthetic process; and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in inner ear disease and primary biliary cholangitis. Orthologous to several human genes including TIGD4 (tigger transposable element derived 4). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See PDC2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (607304..610081, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene TFIIH complex subunit TFB5 Neighboring gene Vps41p Neighboring gene Stn1p Neighboring gene 25S rRNA (adenine645-N1)-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterisation of PDC2, a gene necessary for high level expression of pyruvate decarboxylase structural genes in Saccharomyces cerevisiae. Hohmann S. Mol Gen Genet, 1993 Dec. PMID 8264540
  2. Construction of low-ethanol-wine yeasts through partial deletion of the Saccharomyces cerevisiae PDC2 gene. Cuello RA, et al. AMB Express, 2017 Dec. PMID 28324615, Free PMC Article
  3. Pyruvate decarboxylase and thiamine biosynthetic genes are regulated differently by Pdc2 in S. cerevisiae and C. glabrata. Iosue CL, et al. PLoS One, 2023. PMID 37285346, Free PMC Article
  4. Suppression of pdc2 regulating pyruvate decarboxylase synthesis in yeast. Velmurugan S, et al. Genetics, 1997 Mar. PMID 9055069, Free PMC Article
  5. Thiamin-dependent transactivation activity of PDC2 in Saccharomyces cerevisiae. Nosaka K, et al. FEBS Lett, 2008 Dec 10. PMID 19013460

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pyruvate decarboxylase and thiamine biosynthetic genes are regulated differently by Pdc2 in S. cerevisiae and C. glabrata.
    Title: Pyruvate decarboxylase and thiamine biosynthetic genes are regulated differently by Pdc2 in S. cerevisiae and C. glabrata.
  2. Thi3p causes a conformational change in Pdc2p leading to full transactivation activity under favorable conditions.
    Title: Thiamin-dependent transactivation activity of PDC2 in Saccharomyces cerevisiae.
  3. Pdc2 is required for the upregulation of all genes controlled by thiamine availability
    Title: Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of glycolytic fermentation to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of thiamine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of thiamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
Pdc2p
NP_010366.1
  • Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    607304..610081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180389.1 → NP_010366.1  TPA: Pdc2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010366.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS68, E9PAG9, P32896
    UniProtKB/TrEMBL
    A6ZY47, B5VFX7, C7GVQ5, N1PAC9
    Conserved Domains (3) summary
    PLN02217
    Location:716 → 829
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    pfam03184
    Location:198 → 406
    DDE_1; DDE superfamily endonuclease
    pfam03221
    Location:72 → 135
    HTH_Tnp_Tc5; Tc5 transposase DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32896.2

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