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AFR1 Afr1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851658, updated on 18-Sep-2024

Summary

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Official Symbol
AFR1
Official Full Name
Afr1p
Primary source
SGD:S000002492
Locus tag
YDR085C
See related
AllianceGenome:SGD:S000002492; FungiDB:YDR085C; VEuPathDB:YDR085C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable actin binding activity. Involved in cell morphogenesis involved in conjugation with cellular fusion; protein localization to bud neck; and septin cytoskeleton organization. Located in mating projection base. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See AFR1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (614288..616150, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene 25S rRNA (adenine645-N1)-methyltransferase Neighboring gene Tvp23p Neighboring gene translocon subunit SSS1 Neighboring gene Rrp1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AFR1 acts in conjunction with the alpha-factor receptor to promote morphogenesis and adaptation. Konopka JB. Mol Cell Biol, 1993 Nov. PMID 8413281, Free PMC Article
  2. Afr1p has a role in regulating the localization of Mpk1p at the shmoo tip in Saccharomyces cerevisiae. Changwei Z, et al. FEBS Lett, 2007 Jun 12. PMID 17509572
  3. Functional analysis of the interaction between Afr1p and the Cdc12p septin, two proteins involved in pheromone-induced morphogenesis. Giot L, et al. Mol Biol Cell, 1997 Jun. PMID 9201710, Free PMC Article
  4. Afr1p regulates the Saccharomyces cerevisiae alpha-factor receptor by a mechanism that is distinct from receptor phosphorylation and endocytosis. Davis C, et al. Genetics, 1998 Feb. PMID 9504911, Free PMC Article
  5. Transcriptional interference caused by GCN4 overexpression reveals multiple interactions mediating transcriptional activation. Tavernarakis N, et al. Mol Gen Genet, 1995 Jun 10. PMID 7603436

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicated that, in addition to its role in establishing pheromone-induced morphogenesis, Afr1p may act as a 'sensor' to transduce cell wall stress resulting from different stimuli to the cell integrity pathway, leading to Slt2p activation.
    Title: Afr1p mediates activation of the Slt2p MAP kinase induced by pheromone, heat shock and hypo-osmotic shock in Saccharomyces cerevisiae.
  2. These results demonstrate a previously unknown role for Afr1 in targeting Glc7 to mating projections and in regulating the septin architecture during mating.
    Title: Saccharomyces cerevisiae Afr1 protein is a protein phosphatase 1/Glc7-targeting subunit that regulates the septin cytoskeleton during mating.
  3. Results indicate that deletion of AFR1 results in mislocalization of Mpk1p.
    Title: Afr1p has a role in regulating the localization of Mpk1p at the shmoo tip in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis involved in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to bud neck IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mating projection base IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Afr1p
NP_010370.1
  • Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; also detected in peroxisomes; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    614288..616150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180393.1 → NP_010370.1  TPA: Afr1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010370.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS72, P33304
    UniProtKB/TrEMBL
    B3LGI6, N1P4N5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33304.1

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