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RLI1 Fe-S cluster-binding ribosome biosynthesis protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 851665, updated on 18-Sep-2024

Summary

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Official Symbol
RLI1
Official Full Name
Fe-S cluster-binding ribosome biosynthesis protein
Primary source
SGD:S000002498
Locus tag
YDR091C
See related
AllianceGenome:SGD:S000002498; FungiDB:YDR091C; VEuPathDB:YDR091C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables iron ion binding activity. Involved in several processes, including ribosome biogenesis; ribosome disassembly; and translation. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease. Orthologous to human ABCE1 (ATP binding cassette subfamily E member 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RLI1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (626708..628534, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Vtc5p Neighboring gene Ilt1p Neighboring gene E2 ubiquitin-conjugating protein UBC13 Neighboring gene aminophospholipid-translocating P4-type ATPase DNF2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural organization of essential iron-sulfur clusters in the evolutionarily highly conserved ATP-binding cassette protein ABCE1. Barthelme D, et al. J Biol Chem, 2007 May 11. PMID 17355973
  2. The essential ATP-binding cassette protein RLI1 functions in translation by promoting preinitiation complex assembly. Dong J, et al. J Biol Chem, 2004 Oct 1. PMID 15277527
  3. The ribosomal stalk protein is crucial for the action of the conserved ATPase ABCE1. Imai H, et al. Nucleic Acids Res, 2018 Sep 6. PMID 30010948, Free PMC Article
  4. Cryptococcus neoformans Iron-Sulfur Protein Biogenesis Machinery Is a Novel Layer of Protection against Cu Stress. Garcia-Santamarina S, et al. mBio, 2017 Oct 31. PMID 29089435, Free PMC Article
  5. The Candidate Antimalarial Drug MMV665909 Causes Oxygen-Dependent mRNA Mistranslation and Synergizes with Quinoline-Derived Antimalarials. Vallières C, et al. Antimicrob Agents Chemother, 2017 Sep. PMID 28652237, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. When Rli1 levels were diminished, 80S ribosomes accumulated both at stop codons and in the adjoining 3'UTRs of most mRNAs; Rli1 is crucial for ribosome recycling in vivo and controls ribosome homeostasis.
    Title: Rli1/ABCE1 Recycles Terminating Ribosomes and Controls Translation Reinitiation in 3'UTRs In Vivo.
  2. Collectively, the Yae1-Lto1 complex functions as a target-specific adaptor that recruits apo-Rli1 to the generic cytosolic iron-sulfur assembly machinery.
    Title: The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion.
  3. Data indicate that Rli1p function is a primary target of ROS action.
    Title: The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species.
  4. although the Fe-S cluster is not required for the interaction of Rli1 with eRF1 or its other interacting partner, Hcr1, from the initiation complex eIF3, it is required for its activity in translation termination
    Title: The iron-sulphur protein RNase L inhibitor functions in translation termination.
  5. ribosome biogenesis and function are intimately linked to the crucial role of mitochondria in the maturation of the essential Fe/S protein Rli1p
    Title: Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosomal small subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome disassembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosome disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translational termination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational termination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in translational termination IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Fe-S cluster-binding ribosome biosynthesis protein
NP_010376.3
  • Essential Fe-S protein; required for ribosome biogenesis, translation initiation/termination; facilitates binding of multifactor complex (MFC) of initiation factors to small ribosomal subunit; Dom34-Hbs1 complex and Rli1p work in dissociating inactive ribosomes, thereby facilitating translation restart; forms complex with Lto1p and Yae1p; dependency on ROS-labile FeS clusters, activity in nuclear ribosomal-subunit export impaired by mild oxidative stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    626708..628534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180399.3 → NP_010376.3  TPA: Fe-S cluster-binding ribosome biosynthesis protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010376.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS78, Q03195
    UniProtKB/TrEMBL
    A6ZY57, B3LGI0, B5VFY8, C7GVP5, C8Z509, G2WAJ6
    Conserved Domains (1) summary
    COG1245
    Location:4 → 603
    Rli1; Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03195.1

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