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ARX1 putative hydrolase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851678, updated on 2-Nov-2024

Summary

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Official Symbol
ARX1
Official Full Name
putative hydrolase
Primary source
SGD:S000002508
Locus tag
YDR101C
See related
AllianceGenome:SGD:S000002508; FungiDB:YDR101C; VEuPathDB:YDR101C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable metal ion binding activity and metallopeptidase activity. Involved in ribosomal large subunit export from nucleus. Located in cytoplasm; nucleolus; and nucleoplasm. Part of preribosome, large subunit precursor. Orthologous to human PA2G4 (proliferation-associated 2G4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ARX1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (655686..657467, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene 14-3-3 family protein BMH2 Neighboring gene Tvp15p Neighboring gene uncharacterized protein Neighboring gene Ste5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear recycling of the pre-60S ribosomal subunit-associated factor Arx1 depends on Rei1 in Saccharomyces cerevisiae. Hung NJ, et al. Mol Cell Biol, 2006 May. PMID 16648468, Free PMC Article
  2. The cytosolic J-protein, Jjj1, and Rei1 function in the removal of the pre-60 S subunit factor Arx1. Meyer AE, et al. J Biol Chem, 2010 Jan 8. PMID 19901025, Free PMC Article
  3. A conserved domain important for association of eukaryotic J-protein co-chaperones Jjj1 and Zuo1 with the ribosome. Kaschner LA, et al. Biochim Biophys Acta, 2015 May. PMID 25639645, Free PMC Article
  4. A dynamic model of proteome changes reveals new roles for transcript alteration in yeast. Lee MV, et al. Mol Syst Biol, 2011 Jul 19. PMID 21772262, Free PMC Article
  5. The Hsp40 chaperone Jjj1 is required for the nucleo-cytoplasmic recycling of preribosomal factors in Saccharomyces cerevisiae. Demoinet E, et al. RNA, 2007 Sep. PMID 17652132, Free PMC Article

See all (164) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. suggest that, in addition to the role of Arx1 during pre-60S nuclear export, the binding of Arx1 conformationally locks the pre-60S subunit and inhibits the premature association of nascent chain-processing factors to the polypeptide tunnel exit
    Title: Cryo-EM structures of Arx1 and maturation factors Rei1 and Jjj1 bound to the 60S ribosomal subunit.
  2. binding of Arx1 at the exit tunnel may position this export factor to prevent premature recruitment of ribosome-associated factors active during translation
    Title: Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel.
  3. both Rei1 and Jjj1 are required for dissociation of Arx1 from the pre-60 S subunit, and the region of Jjj1 that mediates interaction with Rei1 is required in vivo for 60 S subunit biogenesis
    Title: The cytosolic J-protein, Jjj1, and Rei1 function in the removal of the pre-60 S subunit factor Arx1.
  4. Arx1 acts as an export receptor for the 60S subunit.
    Title: Arx1 is a nuclear export receptor for the 60S ribosomal subunit in yeast.
  5. Nuclear recycling of the pre-60S ribosomal subunit-associated factor Arx1 depends on Rei1.
    Title: Nuclear recycling of the pre-60S ribosomal subunit-associated factor Arx1 depends on Rei1 in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosomal large subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative hydrolase
NP_010386.1
  • Nuclear export factor for the ribosomal pre-60S subunit; shuttling factor which directly binds FG rich nucleoporins and facilities translocation through the nuclear pore complex; interacts directly with Alb1p; responsible for Tif6p recycling defects in the absence of Rei1; associated with the ribosomal export complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    655686..657467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180409.1 → NP_010386.1  TPA: putative hydrolase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010386.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS88, Q03862
    UniProtKB/TrEMBL
    A6ZY65, B3LGH3
    Conserved Domains (1) summary
    cl00279
    Location:25 → 285
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03862.1

Gene LinkOut

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