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putative phosphotransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851687, updated on 2-Nov-2024

Summary

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Official Full Name
putative phosphotransferase
Primary source
SGD:S000002516
Locus tag
YDR109C
See related
AllianceGenome:SGD:S000002516; FungiDB:YDR109C; VEuPathDB:YDR109C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables D-ribulokinase activity. Involved in pentose metabolic process. Predicted to be active in cytoplasm. Orthologous to human FGGY (FGGY carbohydrate kinase domain containing). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (673520..675667, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Tmn2p Neighboring gene Trs85p Neighboring gene replication fork barrier binding protein FOB1 Neighboring gene alanine transaminase ALT2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular Identification of d-Ribulokinase in Budding Yeast and Mammals. Singh C, et al. J Biol Chem, 2017 Jan 20. PMID 27909055, Free PMC Article
  2. The COG database: a tool for genome-scale analysis of protein functions and evolution. Tatusov RL, et al. Nucleic Acids Res, 2000 Jan 1. PMID 10592175, Free PMC Article
  3. The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. Jacq C, et al. Nature, 1997 May 29. PMID 9169867
  4. Interrogation of γ-tubulin alleles using high-resolution fitness measurements reveals a distinct cytoplasmic function in spindle alignment. Shulist K, et al. Sci Rep, 2017 Sep 12. PMID 28900268, Free PMC Article
  5. Global analysis of protein phosphorylation in yeast. Ptacek J, et al. Nature, 2005 Dec 1. PMID 16319894

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-ribulokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-ribulokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-ribulokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pentose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pentose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative phosphotransferase
NP_010394.3
  • D-ribulokinase; carbohydrate kinase that specifically converts D-ribulose to D-ribulose 5-phosphate during pentose metabolism; null mutant accumulates D-ribulose and the precursor ribitol; proposed to function as a D-ribulose metabolic repair enzyme; member of the FGGY family of carbohydrate kinases; human homolog, FGGY, is involved in both D-ribulose and ribitol metabolism; human FGGY has been linked to both sporadic amyotrophic lateral sclerosis and bipolar disorder

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    673520..675667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180417.3 → NP_010394.3  TPA: putative phosphotransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010394.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS95, Q04585
    UniProtKB/TrEMBL
    B3LGG6, C8Z525
    Conserved Domains (1) summary
    cd07782
    Location:38 → 703
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04585.1

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