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MKC7 aspartyl protease [ Saccharomyces cerevisiae S288C ]

Gene ID: 851722, updated on 28-Oct-2024

Summary

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Official Symbol
MKC7
Official Full Name
aspartyl protease
Primary source
SGD:S000002551
Locus tag
YDR144C
See related
AllianceGenome:SGD:S000002551; FungiDB:YDR144C; VEuPathDB:YDR144C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YPS2
Summary
Enables aspartic-type endopeptidase activity. Involved in fungal-type cell wall organization and signal transduction involved in filamentous growth. Located in fungal-type cell wall. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See MKC7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (744311..746101, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pex7p Neighboring gene ubiquitin-protein ligase SAN1 Neighboring gene Taf12p Neighboring gene DNA-binding transcription factor SWI5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heterologous expression of human cholecystokinin in Saccharomyces cerevisiae. Evidence for a lysine-specific endopeptidase in the yeast secretory pathway. Rourke IJ, et al. J Biol Chem, 1997 Apr 11. PMID 9092503
  2. Purification and characterization of the yeast glycosylphosphatidylinositol-anchored, monobasic-specific aspartyl protease yapsin 2 (Mkc7p). Komano H, et al. J Biol Chem, 1999 Aug 20. PMID 10446224
  3. Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases. Zhang W, et al. Biochim Biophys Acta, 1997 Nov 27. PMID 9409808
  4. Expression, processing and secretion of a proteolytically-sensitive insect diuretic hormone by Saccharomyces cerevisiae requires the use of a yeast strain lacking genes encoding the Yap3 and Mkc7 endoproteases found in the secretory pathway. Copley KS, et al. Biochem J, 1998 Mar 15. PMID 9494104, Free PMC Article
  5. Involvement of cell surface glycosyl-phosphatidylinositol-linked aspartyl proteases in alpha-secretase-type cleavage and ectodomain solubilization of human Alzheimer beta-amyloid precursor protein in yeast. Komano H, et al. J Biol Chem, 1998 Nov 27. PMID 9822624

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fungal-type cell wall organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction involved in filamentous growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in fungal-type cell wall IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aspartyl protease
NP_010428.3
  • GPI-anchored aspartyl protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p; MKC7 has a paralog, YPS1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    744311..746101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180451.3 → NP_010428.3  TPA: aspartyl protease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010428.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSC7, P53379
    UniProtKB/TrEMBL
    G2WAP4, N1PAE2
    Conserved Domains (1) summary
    cd05474
    Location:79 → 470
    SAP_like; SAPs, pepsin-like proteinases secreted from pathogens to degrade host proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53379.2

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