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SEC1 Sec1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851742, updated on 2-Nov-2024

Summary

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Official Symbol
SEC1
Official Full Name
Sec1p
Primary source
SGD:S000002571
Locus tag
YDR164C
See related
AllianceGenome:SGD:S000002571; FungiDB:YDR164C; VEuPathDB:YDR164C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables SNARE binding activity. Involved in positive regulation of vesicle fusion and vesicle docking involved in exocytosis. Located in cellular bud neck; cellular bud tip; and plasma membrane. Human ortholog(s) of this gene implicated in West syndrome; developmental and epileptic encephalopathy 4; and familial hemophagocytic lymphohistiocytosis 5. Orthologous to several human genes including STXBP2 (syntaxin binding protein 2) and STXBP3 (syntaxin binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SEC1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (782041..784215, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Nbp2p Neighboring gene U2-type spliceosomal complex subunit CWC15 Neighboring gene Trm82p Neighboring gene exocyst subunit SEC5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Novick P, et al. Proc Natl Acad Sci U S A, 1979 Apr. PMID 377286, Free PMC Article
  2. Cloning and sequencing of the yeast Saccharomyces cerevisiae SEC1 gene localized on chromosome IV. Aalto MK, et al. Yeast, 1991 Aug-Sep. PMID 1767592
  3. Isolation of secretory vesicles from Saccharomyces cerevisiae. Holcomb CL, et al. Anal Biochem, 1987 Nov 1. PMID 3324821
  4. Engineering of vesicle trafficking improves heterologous protein secretion in Saccharomyces cerevisiae. Hou J, et al. Metab Eng, 2012 Mar. PMID 22265825
  5. Molecular characterization of the SEC1 gene of Saccharomyces cerevisiae: subcellular distribution of a protein required for yeast protein secretion. Egerton M, et al. Yeast, 1993 Jul. PMID 8368004

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hsp110 (Sse1 and Sse2) associates with the 19S regulatory particle of the 26S proteasome and interacts with Hsp70 (Ssa1, Ssa2) to facilitate the delivery of Hsp70 substrates for proteasomal degradation.
    Title: Hsp70-Hsp110 chaperones deliver ubiquitin-dependent and -independent substrates to the 26S proteasome for proteolysis in yeast.
  2. upon vesicle arrival, Sec6 is proposed to release Sec9 in favor of Sec6-exocyst assembly and to simultaneously recruit Sec1 to sites of secretion for coordinated SNARE complex formation and membrane fusion.
    Title: Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1.
  3. Data show that yeast Sec1p is required before and after SNARE complex assembly, in support of general requirements for Sec1/Munc18 proteins in both vesicle docking and fusion.
    Title: Yeast Sec1p functions before and after vesicle docking.
  4. Data show that Sec1p binds specifically to the ternary SNARE complex, with no detectable binding to the binary t-SNARE complex or any of the three individual SNAREs in their uncomplexed forms.
    Title: Specific SNARE complex binding mode of the Sec1/Munc-18 protein, Sec1p.
  5. Our results suggest that Sec1p couples exocyst-mediated vesicle tethering with SNARE-mediated docking and fusion.
    Title: Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p.
  6. Sec1p directly stimulates SNARE-mediated membrane fusion
    Title: Sec1p directly stimulates SNARE-mediated membrane fusion in vitro.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SNARE binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of vesicle fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle docking involved in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle docking involved in exocytosis IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sec1p
NP_010448.1
  • Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function; interacts directly with essential exocyst subunit Sec6p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    782041..784215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180471.1 → NP_010448.1  TPA: Sec1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010448.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSE4, P30619
    UniProtKB/TrEMBL
    A6ZYC2, B3LGC0, C7GQF5, C8Z578, G2WAR2
    Conserved Domains (1) summary
    COG5158
    Location:1 → 644
    SEC1; Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30619.1

Gene LinkOut

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