TRM82 Trm82p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TRM82
Official Full Name: Trm82p
Primary source: SGD:S000002572
Locus tag: YDR165W
See related: AllianceGenome:SGD:S000002572; FungiDB:YDR165W; VEuPathDB:YDR165W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables enzyme activator activity. Involved in tRNA (guanine-N7)-methylation. Located in cytosol and nucleus. Part of tRNA (m7G46) methyltransferase complex. Used to study Seckel syndrome. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and microcephaly, growth deficiency, seizures, and brain malformations. Orthologous to human WDR4 (WD repeat domain 4). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

a second role of Trm82p is to stabilize Trm8p in an active conformation
Title: tRNA m7G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables enzyme activator activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA (guanine-N7)-methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA (guanine-N7)-methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA (guanine-N7)-methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of tRNA (m7G46) methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of tRNA methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info

NP_010449.1

Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p; relocalizes to the cytosol in response to hypoxia; mutation in human ortholog WDR4 causes microcephalic primordial dwarfism

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The following sections contain reference sequences that belong to a specific genome build. Explain