SEC7 Arf family guanine nucleotide exchange factor SEC7 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SEC7
Official Full Name: Arf family guanine nucleotide exchange factor SEC7
Primary source: SGD:S000002577
Locus tag: YDR170C
See related: AllianceGenome:SGD:S000002577; FungiDB:YDR170C; VEuPathDB:YDR170C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in autophagosome assembly; endoplasmic reticulum to Golgi vesicle-mediated transport; and intra-Golgi vesicle-mediated transport. Acts upstream of or within cytoplasm protein quality control. Located in cytoplasmic vesicle; cytosol; and trans-Golgi network. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF1 (ADP ribosylation factor guanine nucleotide exchange factor 1) and ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SEC7 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (796193..802222, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The yeast guanine nucleotide exchange factor Sec7 is a bottleneck in spatial protein quality control and detoxifies neurological disease proteins.
Title: The yeast guanine nucleotide exchange factor Sec7 is a bottleneck in spatial protein quality control and detoxifies neurological disease proteins.
results support a model in which the inter- and intramolecular interactions of the homology upstream of Sec7 ( HUS) box and the C terminus are necessary for the allosteric activation of Sec7.
Title: The HUS box is required for allosteric regulation of the Sec7 Arf-GEF.
The DCB/HUS domain amplifies the ability of Sec7 to activate Arf1 on the membrane surface by facilitating membrane insertion of the Arf1 amphipathic helix.
Title: The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase.
Sec7 is an effector of the Ypt1 and Ypt31/32 GTPases.
Title: Four GTPases differentially regulate the Sec7 Arf-GEF to direct traffic at the trans-golgi network.
Crystallographic, NMR spectrum and mutagenesis studies suggested that the loop>J motif with a key conserved residue Ile1010 modulates the fine conformation of Sec7 domain and thereby regulates its guanine exchange activity.
Title: C-terminal motif within Sec7 domain regulates guanine nucleotide exchange activity via tuning protein conformation.
analysis of the C-terminal sequence in the guanine nucleotide exchange factor Sec7 that mediates Golgi association and interaction with the Rsp5 ubiquitin ligase
Title: A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytoplasm protein quality control	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intra-Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Arf family guanine nucleotide exchange factor SEC7

NP_010454.3

Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors; involved in intra-Golgi transport, ER-to-Golgi transport and proliferation of the Golgi; role in directing misfolded proteins to insoluble deposition sites and detoxifying neurological disease proteins; found in the cytoplasm and on Golgi-associated coated vesicles

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

796193..802222 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180477.3 → NP_010454.3 TPA: Arf family guanine nucleotide exchange factor SEC7 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010454.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSF1, P11075, Q03960, Q04139

UniProtKB/TrEMBL

A6ZYC8

Conserved Domains (2) summary

COG5307
Location:504 → 1693

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

pfam16213
Location:283 → 426

DCB; dimerization and cyclophilin-binding domain of Mon2