SUP35 translation termination factor GTPase eRF3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SUP35
Official Full Name: translation termination factor GTPase eRF3
Primary source: SGD:S000002579
Locus tag: YDR172W
See related: AllianceGenome:SGD:S000002579; FungiDB:YDR172W; VEuPathDB:YDR172W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GST1; PNM2; SAL3; SUF12; SUP2; SUP36
Summary: Enables ribosome binding activity and translation release factor activity. Involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay and translational termination. Located in cytoplasmic stress granule. Part of translation release factor complex. Orthologous to several human genes including GSPT1 (G1 to S phase transition 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SUP35 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (808324..810381)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Yeast Prion Protein Sup35 Initiates alpha-Synuclein Pathology in Parkinson's Disease.
Title: Yeast Prion Protein Sup35 Initiates α-Synuclein Pathology in Parkinson's Disease.
Gene Expression Analysis of Yeast Strains with a Nonsense Mutation in the eRF3-Coding Gene Highlights Possible Mechanisms of Adaptation.
Title: Gene Expression Analysis of Yeast Strains with a Nonsense Mutation in the eRF3-Coding Gene Highlights Possible Mechanisms of Adaptation.
The yeast prion protein Sup35 initiates alpha-synuclein pathology in mouse models of Parkinson's disease.
Title: The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson's disease.
Substoichiometric Hsp104 regulates the genesis and persistence of self-replicable amyloid seeds of Sup35 prion domain.
Title: Substoichiometric Hsp104 regulates the genesis and persistence of self-replicable amyloid seeds of Sup35 prion domain.
Yeast J-protein Sis1 prevents prion toxicity by moderating depletion of prion protein.
Title: Yeast J-protein Sis1 prevents prion toxicity by moderating depletion of prion protein.
Gene Amplification as a Mechanism of Yeast Adaptation to Nonsense Mutations in Release Factor Genes.
Title: Gene Amplification as a Mechanism of Yeast Adaptation to Nonsense Mutations in Release Factor Genes.
Mechanisms that ensure speed and fidelity in eukaryotic translation termination.
Title: Mechanisms that ensure speed and fidelity in eukaryotic translation termination.
Clustering and Fibril Formation during GNNQQNY Aggregation: A Molecular Dynamics Study.
Title: Clustering and Fibril Formation during GNNQQNY Aggregation: A Molecular Dynamics Study.
Aggregation and Prion-Inducing Properties of the G-Protein Gamma Subunit Ste18 are Regulated by Membrane Association.
Title: Aggregation and Prion-Inducing Properties of the G-Protein Gamma Subunit Ste18 are Regulated by Membrane Association.
Nucleation seed size determines amyloid clearance and establishes a barrier to prion appearance in yeast.
Title: Nucleation seed size determines amyloid clearance and establishes a barrier to prion appearance in yeast.

Submit: New GeneRIF Correction See all GeneRIFs (142)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	HDA more info	PubMed
enables ribosome binding	IDA Inferred from Direct Assay more info	PubMed
enables translation release factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation release factor activity	IDA Inferred from Direct Assay more info	PubMed
enables translation release factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational termination	IDA Inferred from Direct Assay more info	PubMed
involved_in translational termination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
part_of translation release factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of translation release factor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: translation termination factor GTPase eRF3

NP_010457.3

Translation termination factor eRF3; has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that modifies cellular fitness, alters translational fidelity by affecting reading frame selection, and results in a nonsense suppressor phenotype; many stress-response genes are repressed in the presence of [PSI(+)]

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

808324..810381

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180479.3 → NP_010457.3 TPA: translation termination factor GTPase eRF3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010457.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSF4, P05420, P05453

UniProtKB/TrEMBL

A0A023T3A2, E9P8G7, H9BH29

Conserved Domains (2) summary

COG5256
Location:254 → 685

TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]

PRK10263
Location:30 → 199

PRK10263; DNA translocase FtsK; Provisional