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SPC19 Spc19p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851782, updated on 2-Nov-2024

Summary

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Official Symbol
SPC19
Official Full Name
Spc19p
Primary source
SGD:S000002609
Locus tag
YDR201W
See related
AllianceGenome:SGD:S000002609; FungiDB:YDR201W; VEuPathDB:YDR201W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to microtubule plus-end binding activity. Involved in attachment of spindle microtubules to kinetochore; positive regulation of attachment of spindle microtubules to kinetochore; and positive regulation of microtubule polymerization. Part of DASH complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SPC19 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (856317..856814)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene protein-lysine N-methyltransferase Neighboring gene Vps64p Neighboring gene Rav2p Neighboring gene ubiquinone biosynthesis protein COQ4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exhaustive identification of interaction domains using a high-throughput method based on two-hybrid screening and PCR-convergence: molecular dissection of a kinetochore subunit Spc34p. Ikeuchi A, et al. Nucleic Acids Res, 2003 Dec 1. PMID 14627828, Free PMC Article
  2. Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules. Muir KW, et al. Science, 2023 Dec 8. PMID 38060647, Free PMC Article
  3. A method for reverse interactome analysis: High-resolution mapping of interdomain interaction network in Dam1 complex and its specific disorganization based on the interaction domain expression. Ikeuchi A, et al. Biotechnol Prog, 2010 Jul-Aug. PMID 20730753
  4. Implication of a novel multiprotein Dam1p complex in outer kinetochore function. Cheeseman IM, et al. J Cell Biol, 2001 Dec 24. PMID 11756468, Free PMC Article
  5. Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation. Gestaut DR, et al. Nat Cell Biol, 2008 Apr. PMID 18364702, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in attachment of spindle microtubules to kinetochore IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of attachment of spindle microtubules to kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DASH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DASH complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of DASH complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
located_in spindle microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Spc19p
NP_010487.3
  • Essential subunit of Dam1 complex (aka DASH complex); complex couples kinetochores to force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body; SPC19 mRNA level is reduced when downstream gene RAV2 is deleted

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    856317..856814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180509.3 → NP_010487.3  TPA: Spc19p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010487.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSI3, Q03954
    UniProtKB/TrEMBL
    B3LG83, G2WAU9, N1P6J3
    Conserved Domains (1) summary
    pfam08287
    Location:6 → 129
    DASH_Spc19; Spc19
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03954.1

Gene LinkOut

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