EBS1 Ebs1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: EBS1
Official Full Name: Ebs1p
Primary source: SGD:S000002614
Locus tag: YDR206W
See related: AllianceGenome:SGD:S000002614; FungiDB:YDR206W; VEuPathDB:YDR206W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable telomerase RNA binding activity and telomeric DNA binding activity. Involved in DNA recombination; negative regulation of translation; and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in P-body. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See EBS1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (862054..864708)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ebs1p is involved in nonsense-mediated RNA decay and behaves similarly to human Smg proteins.
Title: Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.
Ebs1p inhibits translation, most likely through effects on eIF-4E rather than on decapping.
Title: Ebs1p, a negative regulator of gene expression controlled by the Upf proteins in the yeast Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables telomerase RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in P-body	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of telomerase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ebs1p

NP_010492.3

Protein involved in translation inhibition and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors; EBS1 has a paralog, EST1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

862054..864708

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180514.3 → NP_010492.3 TPA: Ebs1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010492.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSI7, Q03466

UniProtKB/TrEMBL

C7GMZ3, N1P8E2

Conserved Domains (2) summary

pfam10373
Location:228 → 516

EST1_DNA_bind; Est1 DNA/RNA binding domain

pfam10374
Location:80 → 214

EST1; Telomerase activating protein Est1