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UPC2 Upc2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851799, updated on 2-Nov-2024

Summary

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Official Symbol
UPC2
Official Full Name
Upc2p
Primary source
SGD:S000002621
Locus tag
YDR213W
See related
AllianceGenome:SGD:S000002621; FungiDB:YDR213W; VEuPathDB:YDR213W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MOX4
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of filamentous growth of a population of unicellular organisms in response to starvation; and positive regulation of sterol import. Located in membrane and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See UPC2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (889751..892492)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF2B catalytic subunit epsilon Neighboring gene chaperonin-containing T-complex alpha subunit TCP1 Neighboring gene Aha1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomic analyses of anaerobically induced genes in Saccharomyces cerevisiae: functional roles of Rox1 and other factors in mediating the anoxic response. Kwast KE, et al. J Bacteriol, 2002 Jan. PMID 11741867, Free PMC Article
  2. A mutation in a purported regulatory gene affects control of sterol uptake in Saccharomyces cerevisiae. Crowley JH, et al. J Bacteriol, 1998 Aug. PMID 9696767, Free PMC Article
  3. Crystallization and preliminary X-ray crystallographic analysis of sterol transcription factor Upc2 from Saccharomyces cerevisiae. Ha S, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Feb 1. PMID 23385756, Free PMC Article
  4. The yeast anaerobic response element AR1b regulates aerobic antifungal drug-dependent sterol gene expression. Gallo-Ebert C, et al. J Biol Chem, 2013 Dec 6. PMID 24163365, Free PMC Article
  5. Metabolic engineering to produce sesquiterpenes in yeast. Jackson BE, et al. Org Lett, 2003 May 15. PMID 12735738

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2ADelta Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis.
    Title: Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2AΔ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis.
  2. Cells lacking both ECM22 and UPC2 display strong mating defects whereas deletion of either gene has no effect. Ecm22 and Upc2 positively regulate basal expression of PRM1 and PRM4. These genes are strongly induced in response to mating pheromone, which is also largely dependent on ECM22 and UPC2.
    Title: Ecm22 and Upc2 regulate yeast mating through control of expression of the mating genes PRM1 and PRM4.
  3. Overexpression of either ECM22 or UPC2 leads to increased filamentation.
    Title: The zinc cluster proteins Upc2 and Ecm22 promote filamentation in Saccharomyces cerevisiae by sterol biosynthesis-dependent and -independent pathways.
  4. Perinuclear localization of Upc2p-GFP and Ecm22p-GFP was increased when ergosterol biosynthesis was blocked by azole drug treatment.
    Title: Cytoplasmic localization of sterol transcription factors Upc2p and Ecm22p in S. cerevisiae.
  5. Upc2p and Ecm22p differ in their contributions to the regulation of their targets
    Title: Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae: similar activation/regulatory domains but different response mechanisms.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of filamentous growth of a population of unicellular organisms in response to starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of filamentous growth of a population of unicellular organisms in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of sterol import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Upc2p
NP_010499.1
  • Sterol regulatory element binding protein; induces sterol biosynthetic genes, upon sterol depletion; acts as a sterol sensor, binding ergosterol in sterol rich conditions; relocates from intracellular membranes to perinuclear foci upon sterol depletion; redundant activator of filamentation with ECM22, up-regulating the expression of filamentous growth genes; contains a Zn[2]-Cys[6] binuclear cluster; UPC2 has a paralog, ECM22, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    889751..892492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180521.1 → NP_010499.1  TPA: Upc2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010499.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSJ7, Q12151
    UniProtKB/TrEMBL
    A6ZYG9, C7GMI6, N1P4Z4
    Conserved Domains (2) summary
    smart00066
    Location:46 → 87
    GAL4; GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
    cl23766
    Location:612 → 753
    fungal_TF_MHR; fungal transcription factor regulatory middle homology region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12151.1

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