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IVY1 Ivy1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851815, updated on 1-Aug-2024

Summary

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Gene symbol
IVY1
Gene description
Ivy1p
Primary source
FungiDB:YDR229W
Locus tag
YDR229W
See related
SGD:S000002637; AllianceGenome:SGD:S000002637; VEuPathDB:YDR229W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phospholipid binding activity. Involved in vacuole fusion, non-autophagic. Located in fungal-type vacuole membrane and membrane raft. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See IVY1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (924785..926146)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene chromatin-silencing protein SIR4 Neighboring gene Pcf11p Neighboring gene Cox20p Neighboring gene 5-aminolevulinate synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast Ivy1p Is a Putative I-BAR-domain Protein with pH-sensitive Filament Forming Ability in vitro. Itoh Y, et al. Cell Struct Funct, 2016. PMID 26657738
  2. A novel phospholipid-binding protein from the yeast Saccharomyces cerevisiae with dual binding specificities for the transport GTPase Ypt7p and the Sec1-related Vps33p. Lazar T, et al. Eur J Cell Biol, 2002 Dec. PMID 12553664
  3. Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor. Malia PC, et al. Proc Natl Acad Sci U S A, 2018 May 1. PMID 29674454, Free PMC Article
  4. Ivy1 is a negative regulator of Gtr-dependent TORC1 activation. Varlakhanova NV, et al. J Cell Sci, 2018 Sep 7. PMID 30097557, Free PMC Article
  5. Role of Atg8 in the regulation of vacuolar membrane invagination. Ishii A, et al. Sci Rep, 2019 Oct 15. PMID 31616012, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ivy1 colocalizes with Gtr1 and Gtr2, a heterodimer of small GTPases that are part of the EGO complex.
    Title: Ivy1 is a negative regulator of Gtr-dependent TORC1 activation.
  2. data suggest that Ivy1 modulates Fab1-mediated PI-3,5-P2 synthesis during membrane stress and may allow adjustment of the vacuole membrane environment.
    Title: Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor.
  3. pH-sensitive polymer forming ability and the functional conservation of Ivy1p in eukaryotic cells
    Title: Yeast Ivy1p Is a Putative I-BAR-domain Protein with pH-sensitive Filament Forming Ability in vitro.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in vacuole fusion, non-autophagic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuole fusion, non-autophagic IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuole fusion, non-autophagic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vacuole fusion, non-autophagic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuole fusion, non-autophagic IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ivy1p
NP_010515.3
  • Phospholipid-binding protein that interacts with both Ypt7p and Vps33p; may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase; contains a putative inverse BAR (I-BAR) domain that can mold lipid bilayer membranes into protrusions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    924785..926146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180537.3 → NP_010515.3  TPA: Ivy1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010515.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSL1, Q04934
    UniProtKB/TrEMBL
    A6ZYI3, B3LG58, C7GVC3, C8Z5E0, G2WAX4, N1P509
    Conserved Domains (1) summary
    cl01115
    Location:201 → 251
    BMFP; Membrane fusogenic activity
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04934.1

Gene LinkOut

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