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BTT1 CCR4-NOT core subunit BTT1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851839, updated on 18-Sep-2024

Summary

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Official Symbol
BTT1
Official Full Name
CCR4-NOT core subunit BTT1
Primary source
SGD:S000002660
Locus tag
YDR252W
See related
AllianceGenome:SGD:S000002660; FungiDB:YDR252W; VEuPathDB:YDR252W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables unfolded protein binding activity. Involved in posttranslational protein targeting to endoplasmic reticulum membrane. Part of CCR4-NOT core complex and nascent polypeptide-associated complex. Orthologous to human BTF3 (basic transcription factor 3) and BTF3L4 (basic transcription factor 3 like 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BTT1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (963412..963861)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pam1p Neighboring gene Met32p Neighboring gene Chl4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast BTF3 protein is encoded by duplicated genes and inhibits the expression of some genes in vivo. Hu GZ, et al. Nucleic Acids Res, 1994 Jul 25. PMID 8052529, Free PMC Article
  2. Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast. Takahashi T, et al. J Toxicol Sci, 2009 Dec. PMID 19952507
  3. The nascent polypeptide-associated complex (NAC) of yeast functions in the targeting process of ribosomes to the ER membrane. Wiedmann B, et al. FEBS Lett, 1999 Sep 10. PMID 10518932
  4. Initial characterization of the nascent polypeptide-associated complex in yeast. Reimann B, et al. Yeast, 1999 Mar 30. PMID 10219998
  5. Functional Dissection of the Nascent Polypeptide-Associated Complex in Saccharomyces cerevisiae. Ott AK, et al. PLoS One, 2015. PMID 26618777, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast.
    Title: Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cotranslational protein targeting to membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CCR4-NOT core complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nascent polypeptide-associated complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nascent polypeptide-associated complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CCR4-NOT core subunit BTT1
NP_010538.1
  • Heterotrimeric nascent polypeptide-associated complex beta3 subunit; complex binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3; BTT1 has a paralog, EGD1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    963412..963861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180560.1 → NP_010538.1  TPA: CCR4-NOT core subunit BTT1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010538.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZYK4, D6VSN2, P40314
    UniProtKB/TrEMBL
    B3LG38, C7GTI7, C8Z5G4, G2WAZ5, N1P6P4
    Conserved Domains (1) summary
    cd22055
    Location:9 → 125
    NAC_BTF3; basal transcription factor BTF3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40314.1

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