AKR1 palmitoyltransferase AKR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: AKR1
Official Full Name: palmitoyltransferase AKR1
Primary source: SGD:S000002672
Locus tag: YDR264C
See related: AllianceGenome:SGD:S000002672; FungiDB:YDR264C; VEuPathDB:YDR264C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables G-protein beta/gamma-subunit complex binding activity and palmitoyltransferase activity. Involved in several processes, including negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion; protein palmitoylation; and protein targeting to membrane. Located in Golgi apparatus. Orthologous to human ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Akr1 acts as a protein acyltransferase for Lcb4.
Title: Long-chain base kinase Lcb4 Is anchored to the membrane through its palmitoylation by Akr1.
the protein palmitoyl transferase Akr1 has transmembrane domains with key roles
Title: Transmembrane topology of the protein palmitoyl transferase Akr1.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables G-protein beta/gamma-subunit complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein palmitoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_010550.1

Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication; any of several human homologs encoding DHHC-type zinc fingers (ZDHHC) can complement temperature sensitivity of yeast akr1 null mutant

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The following sections contain reference sequences that belong to a specific genome build. Explain