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PFU1 Pfu1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851900, updated on 2-Nov-2024

Summary

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Official Symbol
PFU1
Official Full Name
Pfu1p
Primary source
SGD:S000002714
Locus tag
YDR306C
See related
AllianceGenome:SGD:S000002714; FungiDB:YDR306C; VEuPathDB:YDR306C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PFU1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1073735..1075171, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase family protein CPR5 Neighboring gene bis(5'-adenosyl)-triphosphatase Neighboring gene tRNA-Val Neighboring gene putative dolichyl-phosphate-mannose--protein mannosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sgt1p contributes to cyclic AMP pathway activity and physically interacts with the adenylyl cyclase Cyr1p/Cdc35p in budding yeast. Dubacq C, et al. Eukaryot Cell, 2002 Aug. PMID 12456005, Free PMC Article
  2. Systematic analysis of F-box proteins reveals a new branch of the yeast mating pathway. Rangarajan N, et al. J Biol Chem, 2019 Oct 4. PMID 31399514, Free PMC Article
  3. SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis. Willems AR, et al. Philos Trans R Soc Lond B Biol Sci, 1999 Sep 29. PMID 10582239, Free PMC Article
  4. A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. Liu Y, et al. EMBO J, 2009 Nov 4. PMID 19763088, Free PMC Article
  5. Identification of F-box proteins that are involved in resistance to methylmercury in Saccharomyces cerevisiae. Hwang GW, et al. FEBS Lett, 2006 Dec 22. PMID 17141224

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCF ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Pfu1p
NP_010592.1
  • F-box protein that regulates pheromone-dependent morphogenesis; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1073735..1075171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180614.1 → NP_010592.1  TPA: Pfu1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010592.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VST5, Q06640
    UniProtKB/TrEMBL
    A6ZYQ4, B3LFZ0, B5VGI5, C7GQV6, C8Z5L7
    Conserved Domains (1) summary
    pfam13306
    Location:275 → 379
    LRR_5; Leucine rich repeats (6 copies)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06640.1

Gene LinkOut

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