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GIC2 Gic2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851904, updated on 2-Nov-2024

Summary

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Official Symbol
GIC2
Official Full Name
Gic2p
Primary source
SGD:S000002717
Locus tag
YDR309C
See related
AllianceGenome:SGD:S000002717; FungiDB:YDR309C; VEuPathDB:YDR309C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphatidylinositol-4,5-bisphosphate binding activity and small GTPase binding activity. Involved in several processes, including Cdc42 protein signal transduction; positive regulation of formin-nucleated actin cable assembly; and regulation of exit from mitosis. Located in several cellular components, including cellular bud tip; incipient cellular bud site; and mating projection tip. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GIC2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1079048..1080199, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative dolichyl-phosphate-mannose--protein mannosyltransferase Neighboring gene Srb7p Neighboring gene Sum1p Neighboring gene TFIIH/NER complex subunit TFB1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of Gic2 localization and function by phosphatidylinositol 4,5-bisphosphate during the establishment of cell polarity in budding yeast. Orlando K, et al. J Biol Chem, 2008 May 23. PMID 18387956, Free PMC Article
  2. Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p. Chen H, et al. Mol Biol Cell, 2012 Oct. PMID 22918946, Free PMC Article
  3. A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature. Daniels CN, et al. PLoS One, 2018. PMID 30566437, Free PMC Article
  4. The Cdc42 effectors Gic1 and Gic2 regulate polarized post-Golgi secretion. Liu Y, et al. Cell Biosci, 2019. PMID 30988896, Free PMC Article
  5. Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast. Brown JL, et al. Genes Dev, 1997 Nov 15. PMID 9367980, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In yeast cells, Cdc42 polarization involves a positive feedback loop in which effectors called p21-activated kinases (PAKs) act to recruit a Cdc42-directed guanine nucleotide exchange factor (GEF), generating more GTP-Cdc42 in areas that already have GTP-Cdc42. The GTPase-interacting components (GICs) Gic1 and Gic2 are also Cdc42 effectors, and have been implicated in regulation of the actin and septin cytoskeleton.
    Title: A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature.
  2. A novel regulatory input to Bni1p acting through the Cdc42p effector, Gic2p.
    Title: Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p.
  3. phosphatidylinositol 4,5-bisphosphate and Cdc42 act in concert to regulate polarized localization and function of Gic2 during polarized cell growth in the budding yeast
    Title: Regulation of Gic2 localization and function by phosphatidylinositol 4,5-bisphosphate during the establishment of cell polarity in budding yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of formin-nucleated actin cable assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septin ring organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in septin ring organization IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
Gic2p
NP_010595.1
  • Rho-family GTPase interacting protein and Cdc42p effector; required with Gic1p for cell polarity establishment and initiation of budding; involved in recruitment of septins to the presumptive bud site; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region; gic1 gic2 double mutants are defective for polarizing Cdc42p at elevated temperature, so may function both up- and downstream of Cdc42p; regulates mitotic exit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1079048..1080199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180617.1 → NP_010595.1  TPA: Gic2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010595.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VST8, Q06648
    UniProtKB/TrEMBL
    A6ZYQ7, B3LFY7, B5VGI7, C7GQV9, C8Z5M0, G2WB47, N1P746
    Conserved Domains (1) summary
    cd00132
    Location:132 → 169
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06648.1

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