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SSF2 rRNA-binding ribosome biosynthesis protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 851907, updated on 18-Sep-2024

Summary

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Official Symbol
SSF2
Official Full Name
rRNA-binding ribosome biosynthesis protein
Primary source
SGD:S000002720
Locus tag
YDR312W
See related
AllianceGenome:SGD:S000002720; FungiDB:YDR312W; VEuPathDB:YDR312W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables rRNA binding activity. Involved in ribosomal large subunit assembly. Located in nucleolus. Orthologous to several human genes including PPAN-P2RY11 (PPAN-P2RY11 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SSF2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1087581..1088942)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Sum1p Neighboring gene TFIIH/NER complex subunit TFB1 Neighboring gene phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase Neighboring gene Rad34p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A nucleolar protein that affects mating efficiency in Saccharomyces cerevisiae by altering the morphological response to pheromone. Kim J, et al. Genetics, 1998 Jun. PMID 9611192, Free PMC Article
  2. Increased RNA production in Saccharomyces cerevisiae by simultaneously overexpressing FHL1, IFH1, and SSF2 and deleting HRP1. Guo X, et al. Appl Microbiol Biotechnol, 2020 Sep. PMID 32715361
  3. An essential gene pair in Saccharomyces cerevisiae with a potential role in mating. Yu Y, et al. DNA Cell Biol, 1995 May. PMID 7748491
  4. A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR. Dhillon N, et al. Mol Cell, 2000 Oct. PMID 11090616
  5. Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes. Bogengruber E, et al. FEMS Yeast Res, 2003 Mar. PMID 12702244

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased RNA production in Saccharomyces cerevisiae by simultaneously overexpressing FHL1, IFH1, and SSF2 and deleting HRP1.
    Title: Increased RNA production in Saccharomyces cerevisiae by simultaneously overexpressing FHL1, IFH1, and SSF2 and deleting HRP1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rRNA-binding ribosome biosynthesis protein
NP_010598.3
  • Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1087581..1088942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180620.3 → NP_010598.3  TPA: rRNA-binding ribosome biosynthesis protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010598.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSU1, Q12153
    UniProtKB/TrEMBL
    A6ZYR0, B3LFY4, C8Z5M3, N1P581
    Conserved Domains (1) summary
    smart00879
    Location:26 → 220
    Brix; The Brix domain is found in a number of eukaryotic proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12153.1

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