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UBX5 Ubx5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851930, updated on 7-Jul-2024

Summary

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Gene symbol
UBX5
Gene description
Ubx5p
Primary source
FungiDB:YDR330W
Locus tag
YDR330W
See related
SGD:S000002738; AllianceGenome:SGD:S000002738; VEuPathDB:YDR330W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Orthologous to human UBXN7 (UBX domain protein 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See UBX5 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1127872..1129374)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene SCF ubiquitin ligase subunit SKP1 Neighboring gene Pex3p Neighboring gene GPI-anchor transamidase Neighboring gene double-stranded DNA-dependent ATPase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Knowledge-based analysis of microarray gene expression data by using support vector machines. Brown MP, et al. Proc Natl Acad Sci U S A, 2000 Jan 4. PMID 10618406, Free PMC Article
  2. ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors. Marshall RS, et al. Cell, 2019 Apr 18. PMID 30955882, Free PMC Article
  3. The UBX domain: a widespread ubiquitin-like module. Buchberger A, et al. J Mol Biol, 2001 Mar 16. PMID 11243799
  4. Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation. Schuberth C, et al. EMBO Rep, 2004 Aug. PMID 15258615, Free PMC Article
  5. The Rsp5 ubiquitin ligase and the AAA-ATPase Cdc48 control the ubiquitin-mediated degradation of the COPII component Sec23. Ossareh-Nazari B, et al. Exp Cell Res, 2010 Dec 10. PMID 20846524

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ubx5p
NP_010617.1
  • UBX domain-containing protein that interacts with Cdc48p; ubiquitin regulatory X is also known as UBX

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1127872..1129374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180638.1 → NP_010617.1  TPA: Ubx5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010617.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSW2, Q06682
    UniProtKB/TrEMBL
    A0A6A5Q027, A6ZYT2, B3LFW7, B5VGL3, C7GWM7, G2WB69, N1PAI0
    Conserved Domains (3) summary
    smart00166
    Location:419 → 494
    UBX; Domain present in ubiquitin-regulatory proteins
    cd02958
    Location:219 → 336
    UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
    cd14346
    Location:3 → 41
    UBA_Ubx5_like; UBA-like domain found in Saccharomyces cerevisiae UBX domain-containing protein 5 (Ubx5) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06682.1

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