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TFC6 transcription factor TFIIIC subunit TFC6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851964, updated on 2-Nov-2024

Summary

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Official Symbol
TFC6
Official Full Name
transcription factor TFIIIC subunit TFC6
Primary source
SGD:S000002770
Locus tag
YDR362C
See related
AllianceGenome:SGD:S000002770; FungiDB:YDR362C; VEuPathDB:YDR362C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to RNA polymerase III type 1 promoter sequence-specific DNA binding activity and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Involved in 5S class rRNA transcription by RNA polymerase III. Part of transcription factor TFIIIC complex. Orthologous to human GTF3C2 (general transcription factor IIIC subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TFC6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1196679..1198697, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Eaf1p Neighboring gene protein-transporting protein BCP1 Neighboring gene Esc2p Neighboring gene tRNA-Lys

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Compromised RNA polymerase III complex assembly leads to local alterations of intergenic RNA polymerase II transcription in Saccharomyces cerevisiae. Wang Q, et al. BMC Biol, 2014 Oct 28. PMID 25348158, Free PMC Article
  2. Structure of the tau60/Delta tau91 subcomplex of yeast transcription factor IIIC: insights into preinitiation complex assembly. Mylona A, et al. Mol Cell, 2006 Oct 20. PMID 17052456
  3. Autoregulation of an RNA polymerase II promoter by the RNA polymerase III transcription factor III C (TF(III)C) complex. Kleinschmidt RA, et al. Proc Natl Acad Sci U S A, 2011 May 17. PMID 21536876, Free PMC Article
  4. Expression, proteolytic analysis, reconstitution, and crystallization of the tau60/tau91 subcomplex of yeast TFIIIC. Mylona A, et al. Protein Expr Purif, 2006 Feb. PMID 16115780
  5. Tau91, an essential subunit of yeast transcription factor IIIC, cooperates with tau138 in DNA binding. Arrebola R, et al. Mol Cell Biol, 1998 Jan. PMID 9418847, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase III general transcription initiation factor activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 5S class rRNA transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase III IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIIC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIIC complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription factor TFIIIC subunit TFC6
NP_010649.1
  • Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1196679..1198697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180670.1 → NP_010649.1  TPA: transcription factor TFIIIC subunit TFC6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010649.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSZ0, Q06339
    UniProtKB/TrEMBL
    A6ZYW0, B3LFU1, N1P5C8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06339.1

Gene LinkOut

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