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FRQ1 frequenin [ Saccharomyces cerevisiae S288C ]

Gene ID: 851979, updated on 2-Nov-2024

Summary

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Official Symbol
FRQ1
Official Full Name
frequenin
Primary source
SGD:S000002781
Locus tag
YDR373W
See related
AllianceGenome:SGD:S000002781; FungiDB:YDR373W; VEuPathDB:YDR373W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme activator activity. Involved in regulation of signal transduction. Located in Golgi membrane. Orthologous to several human genes including NCS1 (neuronal calcium sensor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See FRQ1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1222759..1223331)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative chitinase Neighboring gene Vps74p Neighboring gene mRNA-binding phosphate metabolism regulator Neighboring gene Wip1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and calcium-binding properties of Frq1, a novel calcium sensor in the yeast Saccharomyces cerevisiae. Ames JB, et al. Biochemistry, 2000 Oct 10. PMID 11015193
  2. Molecular interactions of yeast frequenin (Frq1) with the phosphatidylinositol 4-kinase isoform, Pik1. Huttner IG, et al. J Biol Chem, 2003 Feb 14. PMID 12477731
  3. Fission yeast homolog of neuronal calcium sensor-1 (Ncs1p) regulates sporulation and confers calcium tolerance. Hamasaki-Katagiri N, et al. J Biol Chem, 2004 Mar 26. PMID 14722091
  4. Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase. Hendricks KB, et al. Nat Cell Biol, 1999 Aug. PMID 10559922
  5. Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1). Strahl T, et al. J Biol Chem, 2007 Oct 19. PMID 17720810

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
frequenin
NP_010661.3
  • N-myristoylated calcium-binding protein; may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily; human NCS1 functionally complements the heat sensitivity of a frq1 ts mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1222759..1223331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180681.3 → NP_010661.3  TPA: frequenin [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010661.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT04, Q06389
    UniProtKB/TrEMBL
    A6ZYX1, B3LFT0, B5VGQ3, C7GMG4, C8Z5T5, G2WBA9, N1P7A6
    Conserved Domains (1) summary
    COG5126
    Location:4 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06389.2

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