FRQ1 frequenin [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: FRQ1
Official Full Name: frequenin
Primary source: SGD:S000002781
Locus tag: YDR373W
See related: AllianceGenome:SGD:S000002781; FungiDB:YDR373W; VEuPathDB:YDR373W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables enzyme activator activity. Involved in positive regulation of 1-phosphatidylinositol 4-kinase activity and regulation of signal transduction. Located in Golgi membrane. Human ortholog(s) of this gene implicated in cone-rod dystrophy 14; retinitis pigmentosa 48; and torsion dystonia 2. Orthologous to several human genes including NCS1 (neuronal calcium sensor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables enzyme activator activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

NP_010661.3

N-myristoylated calcium-binding protein; may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily; human NCS1 functionally complements the heat sensitivity of a frq1 ts mutant

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The following sections contain reference sequences that belong to a specific genome build. Explain