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ARH1 NADPH-adrenodoxin reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851982, updated on 2-Nov-2024

Summary

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Official Symbol
ARH1
Official Full Name
NADPH-adrenodoxin reductase
Primary source
SGD:S000002784
Locus tag
YDR376W
See related
AllianceGenome:SGD:S000002784; FungiDB:YDR376W; VEuPathDB:YDR376W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables NADPH-adrenodoxin reductase activity. Involved in intracellular iron ion homeostasis and ubiquinone biosynthetic process. Located in mitochondrial inner membrane. Used to study Parkinson's disease; auditory system disease; optic atrophy; and retinitis pigmentosa. Orthologous to human FDXR (ferredoxin reductase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ARH1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1226822..1228303)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Wip1p Neighboring gene bifunctional AAA family ATPase chaperone/translocase BCS1 Neighboring gene F1F0 ATP synthase subunit f Neighboring gene U4/U6-U5 snRNP complex subunit LSM6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of recombinant adrenodoxin reductase homologue (Arh1p) from yeast. Implication in in vitro cytochrome p45011beta monooxygenase system. Lacour T, et al. J Biol Chem, 1998 Sep 11. PMID 9727014
  2. ARH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to the human adrenodoxin reductase. Manzella L, et al. Yeast, 1998 Jun 30. PMID 9818721
  3. Adrenodoxin reductase homolog (Arh1p) of yeast mitochondria required for iron homeostasis. Li J, et al. J Biol Chem, 2001 Jan 12. PMID 11035018
  4. 11 beta-hydroxylase activity in recombinant yeast mitochondria. In vivo conversion of 11-deoxycortisol to hydrocortisone. Dumas B, et al. Eur J Biochem, 1996 Jun 1. PMID 8681964
  5. Predictive reconstruction of the mitochondrial iron-sulfur cluster assembly metabolism: I. The role of the protein pair ferredoxin-ferredoxin reductase (Yah1-Arh1). Alves R, et al. Proteins, 2004 Aug 1. PMID 15211518

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables NADPH-adrenodoxin reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NADPH-adrenodoxin reductase
NP_010664.3
  • Oxidoreductase of the mitochondrial inner membrane; involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1226822..1228303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180684.3 → NP_010664.3  TPA: NADPH-adrenodoxin reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010664.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT08, P32840, P48360
    UniProtKB/TrEMBL
    A6ZYX5, B3LFS6, C8Z5T9, G2WBB3, N1PAI9
    Conserved Domains (1) summary
    cl30539
    Location:18 → 486
    PLN02852; ferredoxin-NADP+ reductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48360.1

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