SIP1 Sip1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SIP1
Official Full Name: Sip1p
Primary source: SGD:S000002830
Locus tag: YDR422C
See related: AllianceGenome:SGD:S000002830; FungiDB:YDR422C; VEuPathDB:YDR422C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to AMP-activated protein kinase activity. Involved in several processes, including positive regulation of pseudohyphal growth; protein phosphorylation; and regulation of protein-containing complex assembly. Located in cytosol; fungal-type vacuole; and vacuolar membrane. Part of nucleotide-activated protein kinase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The mutant strain with only SIP1 expressed could utilize acetate, but neither ethanol nor glycerol.
Title: The beta-subunits of the Snf1 kinase in Saccharomyces cerevisiae, Gal83 and Sip2, but not Sip1, are redundant in glucose derepression and regulation of sterol biosynthesis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to AMP-activated protein kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
contributes_to AMP-activated protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of protein-containing complex assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of nucleotide-activated protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-activated protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of nucleotide-activated protein kinase complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in vacuolar membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

NP_010710.4

One of three alternate beta-subunits of the Snf1p kinase complex; may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions

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The following sections contain reference sequences that belong to a specific genome build. Explain