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PPM1 leucine carboxy methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852045, updated on 18-Sep-2024

Summary

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Official Symbol
PPM1
Official Full Name
leucine carboxy methyltransferase
Primary source
SGD:S000002843
Locus tag
YDR435C
See related
AllianceGenome:SGD:S000002843; FungiDB:YDR435C; VEuPathDB:YDR435C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein C-terminal leucine carboxyl O-methyltransferase activity. Involved in C-terminal protein methylation; cellular protein-containing complex assembly; and regulation of autophagy. Orthologous to human LCMT1 (leucine carboxyl methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PPM1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1332983..1333969, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mRNA-binding protein NPL3 Neighboring gene GPI-anchor transamidase GPI17 Neighboring gene salt homeostasis regulator Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase GPI19

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A. Laxman S, et al. Autophagy, 2014 Feb. PMID 24362312, Free PMC Article
  2. Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity. Leulliot N, et al. J Biol Chem, 2004 Feb 27. PMID 14660564
  3. Influence of genotype and nutrition on survival and metabolism of starving yeast. Boer VM, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18456835, Free PMC Article
  4. Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4. Suzuki Y, et al. Nucleic Acids Res, 2009 May. PMID 19287006, Free PMC Article
  5. Cdc55p-mediated E4orf4 growth inhibition in Saccharomyces cerevisiae is mediated only in part via the catalytic subunit of protein phosphatase 2A. Li Y, et al. J Virol, 2008 Apr. PMID 18216111, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein C-terminal leucine carboxyl O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein C-terminal leucine carboxyl O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein C-terminal leucine carboxyl O-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in C-terminal protein methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
leucine carboxy methyltransferase
NP_010723.1
  • Carboxyl methyltransferase; methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits; required for methionine to inhibit autophagy and promote growth

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1332983..1333969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180743.1 → NP_010723.1  TPA: leucine carboxy methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010723.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT62, Q04081
    UniProtKB/TrEMBL
    B3LFM4, B5VGW6, C7GTN9, N1P788
    Conserved Domains (1) summary
    pfam04072
    Location:5 → 220
    LCM; Leucine carboxyl methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04081.1

Gene LinkOut

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