GPI19 phosphatidylinositol N-acetylglucosaminyltransferase GPI19 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: GPI19
Official Full Name: phosphatidylinositol N-acetylglucosaminyltransferase GPI19
Primary source: SGD:S000002845
Locus tag: YDR437W
See related: AllianceGenome:SGD:S000002845; FungiDB:YDR437W; VEuPathDB:YDR437W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to UDP-glycosyltransferase activity. Involved in GPI anchor biosynthetic process. Is integral component of endoplasmic reticulum membrane. Part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 55. Orthologous to human PIGP (phosphatidylinositol glycan anchor biosynthesis class P). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Data show that Gpi19 (Ydr437w) is a small but essential subunit of the yeast GPI-GlcNAc transferase.
Title: Gpi19, the Saccharomyces cerevisiae homologue of mammalian PIG-P, is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to UDP-glycosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GPI anchor biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	HDA more info	PubMed

NP_010725.3

Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis; shares similarity with mammalian PIG-P

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The following sections contain reference sequences that belong to a specific genome build. Explain