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THI74 Thi74p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852048, updated on 2-Nov-2024

Summary

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Official Symbol
THI74
Official Full Name
Thi74p
Primary source
SGD:S000002846
Locus tag
YDR438W
See related
AllianceGenome:SGD:S000002846; FungiDB:YDR438W; VEuPathDB:YDR438W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Located in mitochondrion. Orthologous to human SLC35F5 (solute carrier family 35 member F5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See THI74 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1338274..1339386)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene salt homeostasis regulator Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase GPI19 Neighboring gene Lrs4p Neighboring gene histone methyltransferase DOT1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic implication of a novel thiamine transporter in human hypertension. Zhang K, et al. J Am Coll Cardiol, 2014 Apr 22. PMID 24509276, Free PMC Article
  2. Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mojzita D, et al. Mol Genet Genomics, 2006 Aug. PMID 16850348
  3. Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase. Wang Y, et al. J Cell Biol, 2020 May 4. PMID 32303746, Free PMC Article
  4. The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts. Scutenaire J, et al. Nucleic Acids Res, 2023 Jan 25. PMID 35934316, Free PMC Article
  5. Association of yeast Upf1p with direct substrates of the NMD pathway. Johansson MJ, et al. Proc Natl Acad Sci U S A, 2007 Dec 26. PMID 18087042, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Thi74p
NP_010726.3
  • Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication; shows sequence homology to human gene SLC35F3, a thiamine transporter implicated in hypertension

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1338274..1339386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180746.3 → NP_010726.3  TPA: Thi74p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010726.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT65, Q04083
    UniProtKB/TrEMBL
    B3LFM1, C7GTP1, C8Z5Z8, N1P8X4
    Conserved Domains (1) summary
    COG0697
    Location:113 → 354
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04083.1

Gene LinkOut

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