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UTP6 snoRNA-binding rRNA-processing protein UTP6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852060, updated on 18-Sep-2024

Summary

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Official Symbol
UTP6
Official Full Name
snoRNA-binding rRNA-processing protein UTP6
Primary source
SGD:S000002857
Locus tag
YDR449C
See related
AllianceGenome:SGD:S000002857; FungiDB:YDR449C; VEuPathDB:YDR449C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables U3 snoRNA binding activity. Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Orthologous to human UTP6 (UTP6 small subunit processome component). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See UTP6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1357580..1358902, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S17B Neighboring gene chromatin-binding transcription regulator ADA2 Neighboring gene ribosomal 40S subunit protein S18A Neighboring gene Yhp1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A structural model for the HAT domain of Utp6 incorporating bioinformatics and genetics. Champion EA, et al. Protein Eng Des Sel, 2009 Jul. PMID 19515729, Free PMC Article
  2. Mammalian HCA66 protein is required for both ribosome synthesis and centriole duplication. Bonnart C, et al. Nucleic Acids Res, 2012 Jul. PMID 22434888, Free PMC Article
  3. Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits. Zhang C, et al. Nucleic Acids Res, 2016 Sep 6. PMID 27330138, Free PMC Article
  4. A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing. Champion EA, et al. Mol Cell Biol, 2008 Nov. PMID 18725399, Free PMC Article
  5. The DEAD-box RNA helicase-like Utp25 is an SSU processome component. Charette JM, et al. RNA, 2010 Nov. PMID 20884785, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The interaction between the half-a-tetratricopeptide repeat (HAT) domain of Utp6 and a specific peptide in Utp21, is investigated.
    Title: A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables U3 snoRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables snoRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 90S preribosome HDA PubMed 
part_of Pwp2p-containing subcomplex of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Pwp2p-containing subcomplex of 90S preribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
snoRNA-binding rRNA-processing protein UTP6
NP_010737.1
  • Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1357580..1358902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180757.1 → NP_010737.1  TPA: snoRNA-binding rRNA-processing protein UTP6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010737.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT74, Q02354, Q04115
    UniProtKB/TrEMBL
    A6ZZ40, B3LFL3, B5VGY0, C7GKP1, C8Z607, N1P7I7
    Conserved Domains (1) summary
    COG5191
    Location:1 → 440
    COG5191; Uncharacterized conserved protein, contains HAT (Half-A-TPR) repeat [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02354.2

Gene LinkOut

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