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PKH3 protein kinase PKH3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852077, updated on 28-Oct-2024

Summary

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Official Symbol
PKH3
Official Full Name
protein kinase PKH3
Primary source
SGD:S000002874
Locus tag
YDR466W
See related
AllianceGenome:SGD:S000002874; FungiDB:YDR466W; VEuPathDB:YDR466W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein kinase activity. Involved in cell integrity MAPK cascade. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PDPK1 (3-phosphoinositide dependent protein kinase 1) and PDPK2P (3-phosphoinositide dependent protein kinase 2, pseudogene). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See PKH3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1395121..1397817)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Spp41p Neighboring gene protein-arginine N5-methyltransferase Neighboring gene Tlg1p Neighboring gene Sdc1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Depletion of yeast PDK1 orthologs triggers a stress-like transcriptional response. Pastor-Flores D, et al. BMC Genomics, 2015 Sep 21. PMID 26391581, Free PMC Article
  2. PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Inagaki M, et al. Mol Cell Biol, 1999 Dec. PMID 10567559, Free PMC Article
  3. Cell cycle-dependent phosphorylation of Sec4p controls membrane deposition during cytokinesis. Lepore D, et al. J Cell Biol, 2016 Sep 12. PMID 27621363, Free PMC Article
  4. A nutrient-responsive pathway that determines M phase timing through control of B-cyclin mRNA stability. Messier V, et al. Cell, 2013 May 23. PMID 23706744
  5. Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis. Mattiazzi Ušaj M, et al. Metallomics, 2015 Sep. PMID 26067383

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell integrity MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein kinase PKH3
NP_010754.1
  • Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p; yeast Pkh1p and Pkh2p are two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1395121..1397817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180774.1 → NP_010754.1  TPA: protein kinase PKH3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010754.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT91, Q03306
    UniProtKB/TrEMBL
    A6ZZ57, B3LFJ8, B5VGZ6, C7GKQ8, C8Z625, G2WBJ7, N1PAK7
    Conserved Domains (1) summary
    cd05581
    Location:9 → 293
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03306.1

Gene LinkOut

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