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PRP3 U4/U6-U5 snRNP complex subunit PRP3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852084, updated on 28-Oct-2024

Summary

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Official Symbol
PRP3
Official Full Name
U4/U6-U5 snRNP complex subunit PRP3
Primary source
SGD:S000002881
Locus tag
YDR473C
See related
AllianceGenome:SGD:S000002881; FungiDB:YDR473C; VEuPathDB:YDR473C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RNA3
Summary
Involved in spliceosomal snRNP assembly. Part of U4/U6 x U5 tri-snRNP complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 18. Orthologous to human PRPF3 (pre-mRNA processing factor 3). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See PRP3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1404445..1405854, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene TRAPP subunit TRS31 Neighboring gene Jip4p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning of Saccharomyces cerevisiae MGC1/YDR473c gene which is essential for cell growth. Fujimura H. Antonie Van Leeuwenhoek, 2000 Jan. PMID 10696880
  2. A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. Liu S, et al. Elife, 2015 Jul 10. PMID 26161500, Free PMC Article
  3. The yeast Prp3 protein is a U4/U6 snRNP protein necessary for integrity of the U4/U6 snRNP and the U4/U6.U5 tri-snRNP. Anthony JG, et al. RNA, 1997 Oct. PMID 9326489, Free PMC Article
  4. Identification and nuclear localization of yeast pre-messenger RNA processing components: RNA2 and RNA3 proteins. Last RL, et al. J Cell Biol, 1986 Dec. PMID 3536958, Free PMC Article
  5. Functional and structural characterization of the prp3 binding domain of the yeast prp4 splicing factor. Ayadi L, et al. J Mol Biol, 1998 Dec 4. PMID 9826507

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal snRNP assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U4/U6 x U5 tri-snRNP complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U4/U6-U5 snRNP complex subunit PRP3
NP_010761.3
  • Splicing factor; component of the U4/U6-U5 snRNP complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1404445..1405854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180781.3 → NP_010761.3  TPA: U4/U6-U5 snRNP complex subunit PRP3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010761.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT97, Q03338
    UniProtKB/TrEMBL
    B3LFJ2, B5VH02, C7GKR3, C8Z632, G2WBK3, N1P901
    Conserved Domains (2) summary
    pfam06544
    Location:342 → 464
    DUF1115; Protein of unknown function (DUF1115)
    pfam08572
    Location:67 → 317
    PRP3; pre-mRNA processing factor 3 (PRP3)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03338.1

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