U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SLD5 DNA replication protein SLD5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852100, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
SLD5
Official Full Name
DNA replication protein SLD5
Primary source
SGD:S000002897
Locus tag
YDR489W
See related
AllianceGenome:SGD:S000002897; FungiDB:YDR489W; VEuPathDB:YDR489W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CDC105
Summary
Involved in DNA-templated DNA replication and double-strand break repair via break-induced replication. Part of CMG complex; GINS complex; and replication fork protection complex. Orthologous to human GINS4 (GINS complex subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SLD5 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1431012..1431896)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3 Neighboring gene dynein intermediate chain Neighboring gene serine/threonine protein kinase PKH1 Neighboring gene PAQR-type receptor

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo. Kanemaki M, et al. Nature, 2003 Jun 12. PMID 12768207
  2. The evolutionary plasticity of chromosome metabolism allows adaptation to constitutive DNA replication stress. Fumasoni M, et al. Elife, 2020 Feb 11. PMID 32043971, Free PMC Article
  3. A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome. Simon AC, et al. Nature, 2014 Jun 12. PMID 24805245, Free PMC Article
  4. Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Kamimura Y, et al. Mol Cell Biol, 1998 Oct. PMID 9742127, Free PMC Article
  5. Ctf4 Links DNA Replication with Sister Chromatid Cohesion Establishment by Recruiting the Chl1 Helicase to the Replisome. Samora CP, et al. Mol Cell, 2016 Aug 4. PMID 27397686, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via break-induced replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CMG complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of DNA replication preinitiation complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of DNA replication preinitiation complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of GINS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GINS complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of replication fork protection complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
DNA replication protein SLD5
NP_010777.3
  • Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1431012..1431896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180797.3 → NP_010777.3  TPA: DNA replication protein SLD5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010777.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTB2, Q03406, Q6Q558
    UniProtKB/TrEMBL
    A6ZZ78, B3LFH7, C7GKS7, C8Z647, G2WBL8, N1P7E9
    Conserved Domains (1) summary
    COG5086
    Location:1 → 294
    COG5086; Uncharacterized conserved protein [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03406.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous