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IZH1 PAQR-type receptor [ Saccharomyces cerevisiae S288C ]

Gene ID: 852102, updated on 17-May-2024

Summary

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Gene symbol
IZH1
Gene description
PAQR-type receptor
Primary source
FungiDB:YDR492W
Locus tag
YDR492W
See related
SGD:S000002900; AllianceGenome:SGD:S000002900; VEuPathDB:YDR492W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable signaling receptor activity. Involved in cellular zinc ion homeostasis. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in breast cancer; macular degeneration; and prostate adenocarcinoma. Orthologous to human ADIPOR1 (adiponectin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See IZH1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1434924..1435874)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene DNA replication protein SLD5 Neighboring gene serine/threonine protein kinase PKH1 Neighboring gene Mzm1p Neighboring gene mitochondrial 37S ribosomal protein RSM28

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor. Narasimhan ML, et al. Mol Cell, 2005 Jan 21. PMID 15664187
  2. Phylogenetic and preliminary phenotypic analysis of yeast PAQR receptors: potential antifungal targets. Villa NY, et al. J Mol Evol, 2011 Oct. PMID 22009226, Free PMC Article
  3. Metalloregulation of yeast membrane steroid receptor homologs. Lyons TJ, et al. Proc Natl Acad Sci U S A, 2004 Apr 13. PMID 15060275, Free PMC Article
  4. An Autophagy-Independent Role for ATG41 in Sulfur Metabolism During Zinc Deficiency. Bucci MD, et al. Genetics, 2018 Mar. PMID 29321173, Free PMC Article
  5. The unfolded protein response is necessary but not sufficient to compensate for defects in disulfide isomerization. Kim JH, et al. J Biol Chem, 2009 Apr 17. PMID 19233841, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PAQR-type receptor
NP_010780.1
  • Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1434924..1435874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180800.1 → NP_010780.1  TPA: PAQR-type receptor [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010780.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTB4, Q03419, Q6Q557
    UniProtKB/TrEMBL
    A0A6A5PZD0, B3LFH5, B5VH19, C7GKS9, C8Z650, G2WBM0, N1PAL2
    Conserved Domains (1) summary
    pfam03006
    Location:75 → 300
    HlyIII; Haemolysin-III related
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03419.1

Gene LinkOut

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