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SEC20 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852109, updated on 22-Aug-2024

Summary

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Official Symbol
SEC20
Primary source
FungiDB:YDR498C
Locus tag
YDR498C
See related
SGD:S000002906; AllianceGenome:SGD:S000002906; VEuPathDB:YDR498C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable SNAP receptor activity. Involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in endoplasmic reticulum. Is integral component of membrane. Part of SNARE complex. Colocalizes with peroxisome. Orthologous to human BNIP1 (BCL2 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SEC20 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1445843..1446994, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Puf6p Neighboring gene myo-inositol transporter ITR1 Neighboring gene Lcd1p Neighboring gene ribosomal 60S subunit protein L37B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast SEC20 gene is required for N- and O-glycosylation in the Golgi. Evidence that impaired glycosylation does not correlate with the secretory defect. Schleip I, et al. J Biol Chem, 2001 Aug 3. PMID 11477110
  2. The Saccharomyces cerevisiae SEC20 gene encodes a membrane glycoprotein which is sorted by the HDEL retrieval system. Sweet DJ, et al. EMBO J, 1992 Feb. PMID 1537327, Free PMC Article
  3. SNARE-mediated retrograde traffic from the Golgi complex to the endoplasmic reticulum. Lewis MJ, et al. Cell, 1996 Apr 19. PMID 8612273
  4. The TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p. Sweet DJ, et al. EMBO J, 1993 Jul. PMID 8334998, Free PMC Article
  5. Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis. Perry RJ, et al. Eukaryot Cell, 2009 Jun. PMID 19346454, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SEC20, SEC39, and DSL1 are essential secretory genes involved in the early stages of peroxisome assembly.
    Title: Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables SNAP receptor activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sec20p
NP_010786.3
  • Membrane glycoprotein v-SNARE; involved in retrograde transport from the Golgi to the endoplasmic reticulum (ER); required for N- and O-glycosylation in the Golgi but not in the ER and for efficient nuclear fusion during mating; mediates Sey1p-independent homotypic ER fusion; interacts with the Dsl1p complex through Tip20p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1445843..1446994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180806.3 → NP_010786.3  TPA: Sec20p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010786.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTC0, P28791
    UniProtKB/TrEMBL
    G2WBM6, N1P7G2
    Conserved Domains (1) summary
    pfam03908
    Location:204 → 295
    Sec20
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28791.1

Gene LinkOut

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