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GIN4 protein kinase GIN4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852119, updated on 3-Nov-2024

Summary

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Official Symbol
GIN4
Official Full Name
protein kinase GIN4
Primary source
SGD:S000002915
Locus tag
YDR507C
See related
AllianceGenome:SGD:S000002915; FungiDB:YDR507C; VEuPathDB:YDR507C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ERC47
Summary
Enables protein kinase activity. Involved in several processes, including budding cell bud growth; mitotic morphogenesis checkpoint signaling; and septin ring assembly. Located in cellular bud neck. Orthologous to human BRSK1 (BR serine/threonine kinase 1) and BRSK2 (BR serine/threonine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GIN4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1462358..1465786, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase Neighboring gene tRNA-Leu Neighboring gene glutamine permease GNP1 Neighboring gene SUMO family protein SMT3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic analysis of Cln/Cdc28 regulation of cell morphogenesis in budding yeast. Benton BK, et al. EMBO J, 1993 Dec 15. PMID 8262069, Free PMC Article
  2. Reciprocal regulation by Elm1 and Gin4 controls septin hourglass assembly and remodeling. Marquardt J, et al. J Cell Biol, 2024 May 6. PMID 38448162, Free PMC Article
  3. Septin-associated protein kinase Gin4 affects localization and phosphorylation of Chs4, the regulatory subunit of the Baker's yeast chitin synthase III complex. Gohlke S, et al. Fungal Genet Biol, 2018 Aug. PMID 29763674
  4. Septins have a dual role in controlling mitotic exit in budding yeast. Castillon GA, et al. Curr Biol, 2003 Apr 15. PMID 12699621
  5. A positive selection for plasmid loss in Saccharomyces cerevisiae using galactose-inducible growth inhibitory sequences. Kawahata M, et al. Yeast, 1999 Jan 15. PMID 10028180

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reciprocal regulation by Elm1 and Gin4 controls septin hourglass assembly and remodeling.
    Title: Reciprocal regulation by Elm1 and Gin4 controls septin hourglass assembly and remodeling.
  2. Growth-Dependent Activation of Protein Kinases Suggests a Mechanism for Measuring Cell Growth.
    Title: Growth-Dependent Activation of Protein Kinases Suggests a Mechanism for Measuring Cell Growth.
  3. To identify unknown binding partners of Chs4, we conducted different screening approaches, which yielded several novel candidates of Chs4-binding proteins including the septin-associated kinase Gin4
    Title: Septin-associated protein kinase Gin4 affects localization and phosphorylation of Chs4, the regulatory subunit of the Baker's yeast chitin synthase III complex.
  4. Gin4 is highly localized control of membrane lipid asymmetry and is necessary for optimal cytokinesis.
    Title: Protein kinase Gin4 negatively regulates flippase function and controls plasma membrane asymmetry.
  5. A requirement for the septin Shs1 and the septin-associated kinase Gin4 for the localization and in vivo activity of the budding yeast Bnr1, is described.
    Title: Regulation of the formin Bnr1 by septins anda MARK/Par1-family septin-associated kinase.
  6. Elm1 regulates the septin assembly-dependent cellular events by directly phosphorylating and activating the Gin4-dependent pathway
    Title: Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in budding cell bud growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in budding cell bud growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic morphogenesis checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization to cell division site IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septin ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein kinase GIN4
NP_010795.3
  • Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; negatively regulates Fpk1p kinase that stimulates phospholipid flippases Dnf1p and Dnf2p; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1462358..1465786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180815.3 → NP_010795.3  TPA: protein kinase GIN4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010795.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTC9, Q12263
    UniProtKB/TrEMBL
    B3LFG1, N1P926
    Conserved Domains (2) summary
    cd12194
    Location:1026 → 1139
    Kcc4p_like_C; C-terminal kinase associated domain 1 (KA1), a phospholipid binding domain, of Kcc4p and similar proteins
    cl21453
    Location:17 → 289
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12263.1

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