U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SLF1 Slf1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852127, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
SLF1
Official Full Name
Slf1p
Primary source
SGD:S000002923
Locus tag
YDR515W
See related
AllianceGenome:SGD:S000002923; FungiDB:YDR515W; VEuPathDB:YDR515W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SRO99
Summary
Enables RNA binding activity. Involved in intracellular copper ion homeostasis and regulation of translation. Located in cytoplasmic stress granule. Orthologous to human LARP1 (La ribonucleoprotein 1, translational regulator) and LARP1B (La ribonucleoprotein 1B). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SLF1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1473429..1474772)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Emi1p Neighboring gene dithiol glutaredoxin GRX2 Neighboring gene uncharacterized protein Neighboring gene putative glucokinase Neighboring gene Grh1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of SLF1 as a new copper homeostasis gene involved in copper sulfide mineralization in Saccharomyces cerevisiae. Yu W, et al. Mol Cell Biol, 1996 May. PMID 8628314, Free PMC Article
  2. Repression of mitochondrial translation, respiration and a metabolic cycle-regulated gene, SLF1, by the yeast Pumilio-family protein Puf3p. Chatenay-Lapointe M, et al. PLoS One, 2011. PMID 21655263, Free PMC Article
  3. Two yeast La motif-containing proteins are RNA-binding proteins that associate with polyribosomes. Sobel SG, et al. Mol Biol Cell, 1999 Nov. PMID 10564276, Free PMC Article
  4. Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs. Jennings MD, et al. Nucleic Acids Res, 2023 Jun 23. PMID 37070186, Free PMC Article
  5. Paralogous translation factors target distinct mRNAs to differentially regulate tolerance to oxidative stress in yeast. Cunningham J, et al. Nucleic Acids Res, 2023 Sep 8. PMID 37449412, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs.
    Title: Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs.
  2. our results indicate that Slf1p mediates a translational response to oxidative stress via mRNA-specific translational control.
    Title: The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response.
  3. Data identified the cytoplasmic translation factor Slf1p as yeast metabolic cycle-regulated gene that is repressed by Puf3p at the post-transcriptional level and promotes respiration and extension of yeast chronological life span when over-expressed.
    Title: Repression of mitochondrial translation, respiration and a metabolic cycle-regulated gene, SLF1, by the yeast Pumilio-family protein Puf3p.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in intracellular copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasmic stress granule HDA PubMed 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Slf1p
NP_010803.3
  • RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; role in preventing L-A mycovirus pathogenesis; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1473429..1474772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180823.3 → NP_010803.3  TPA: Slf1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010803.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTD6, E9P8Z6, Q12034
    UniProtKB/TrEMBL
    G2WBP2, N1P5V3
    Conserved Domains (1) summary
    COG5193
    Location:3 → 443
    LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12034.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools