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FPR2 peptidylprolyl isomerase family protein FPR2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852131, updated on 2-Nov-2024

Summary

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Official Symbol
FPR2
Official Full Name
peptidylprolyl isomerase family protein FPR2
Primary source
SGD:S000002927
Locus tag
YDR519W
See related
AllianceGenome:SGD:S000002927; FungiDB:YDR519W; VEuPathDB:YDR519W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FKB2
Summary
Enables FK506 binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding and protein peptidyl-prolyl isomerization. Located in membrane. Used to study Huntington's disease. Orthologous to several human genes including FKBP2 (FKBP prolyl isomerase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See FPR2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1480425..1480832)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Grh1p Neighboring gene protein disulfide isomerase EUG1 Neighboring gene Urc2p Neighboring gene Sps2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae contains a homolog of human FKBP-13, a membrane-associated FK506/rapamycin binding protein. Partaledis JA, et al. Yeast, 1992 Aug. PMID 1279908
  2. The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. Partaledis JA, et al. Proc Natl Acad Sci U S A, 1993 Jun 15. PMID 7685904, Free PMC Article
  3. Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2. Nielsen JB, et al. Proc Natl Acad Sci U S A, 1992 Aug 15. PMID 1380159, Free PMC Article
  4. A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus. Benton BM, et al. J Cell Biol, 1994 Nov. PMID 7525596, Free PMC Article
  5. Purification of FKBP-70, a novel immunophilin from Saccharomyces cerevisiae, and cloning of its structural gene, FPR3. Manning-Krieg UC, et al. FEBS Lett, 1994 Sep 19. PMID 7925954

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables FK506 binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chaperone-mediated protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
peptidylprolyl isomerase family protein FPR2
NP_010807.3
  • Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress; mutation is functionally complemented by human FKBP2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1480425..1480832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180827.3 → NP_010807.3  TPA: peptidylprolyl isomerase family protein FPR2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010807.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTE0, P32472
    UniProtKB/TrEMBL
    A6ZZA6, B3LFF1, C8Z675, G2WBP6, N1P7I4
    Conserved Domains (1) summary
    COG0545
    Location:39 → 132
    FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32472.1

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