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SPS1 putative serine/threonine protein kinase SPS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852135, updated on 18-Sep-2024

Summary

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Official Symbol
SPS1
Official Full Name
putative serine/threonine protein kinase SPS1
Primary source
SGD:S000002931
Locus tag
YDR523C
See related
AllianceGenome:SGD:S000002931; FungiDB:YDR523C; VEuPathDB:YDR523C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein kinase activity. Involved in several processes, including ascospore wall assembly; meiotic spindle disassembly; and negative regulation of protein localization to nucleolus. Located in cytoplasm; nucleus; and prospore membrane. Orthologous to several human genes including STK26 (serine/threonine kinase 26). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SPS1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1485566..1487038, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Urc2p Neighboring gene Sps2p Neighboring gene GTPase-activating protein AGE1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutation of the SPS1-encoded protein kinase of Saccharomyces cerevisiae leads to defects in transcription and morphology during spore formation. Friesen H, et al. Genes Dev, 1994 Sep 15. PMID 7958886
  2. Characterization and mutational analysis of a cluster of three genes expressed preferentially during sporulation of Saccharomyces cerevisiae. Percival-Smith A, et al. Mol Cell Biol, 1986 Jul. PMID 3023934, Free PMC Article
  3. Meiosis II spindle disassembly requires two distinct pathways. Seitz BC, et al. Mol Biol Cell, 2023 Sep 1. PMID 37436806, Free PMC Article
  4. The GCKIII kinase Sps1 and the 14-3-3 isoforms, Bmh1 and Bmh2, cooperate to ensure proper sporulation in Saccharomyces cerevisiae. Slubowski CJ, et al. PLoS One, 2014. PMID 25409301, Free PMC Article
  5. Role of IME1 expression in regulation of meiosis in Saccharomyces cerevisiae. Smith HE, et al. Mol Cell Biol, 1990 Dec. PMID 2247050, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Noncanonical Hippo Pathway Regulates Spindle Disassembly and Cytokinesis During Meiosis in Saccharomyces cerevisiae.
    Title: A Noncanonical Hippo Pathway Regulates Spindle Disassembly and Cytokinesis During Meiosis in Saccharomyces cerevisiae.
  2. Genetic dissection of prospore membrane closure finds SPS1 and SPO77 act in parallel to a previously described pathway of prospore membrane closure that involves AMA1, an activator of the meiotic anaphase promoting complex.
    Title: Timely Closure of the Prospore Membrane Requires SPS1 and SPO77 in Saccharomyces cerevisiae.
  3. Data suggest that Sps1p promotes sporulation, in part, by regulating the intracellular movement of proteins required for spore wall formation.
    Title: Saccharomyces cerevisiae Sps1p regulates trafficking of enzymes required for spore wall synthesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ascospore formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ascospore wall assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic spindle disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein localization to nucleolus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ascospore-type prospore membrane formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in prospore membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative serine/threonine protein kinase SPS1
NP_010811.1
  • STE20-family GCKIII protein kinase; required for prospore membrane closure, efficient spore packaging, and localization of enzymes involved in spore wall synthesis; component of a non-canonical Hippo pathway with Cdc15p involved in spindle disassembly and sustained release of Cdc14p during anaphase II; forms a complex with Cdc15p; phosphorylation requires Cdc15p; required for Ssp1p phosphorylation and turnover; interacts with 14-3-3 proteins; expressed in late meiosis; nuclear and cytoplasmic

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1485566..1487038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180831.1 → NP_010811.1  TPA: putative serine/threonine protein kinase SPS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010811.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTE3, P08458
    UniProtKB/TrEMBL
    A6ZZA9, C7GKV4, C8Z679, G2WBP9, N1P7R6
    Conserved Domains (1) summary
    cd06609
    Location:16 → 291
    STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08458.2

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