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AGE1 GTPase-activating protein AGE1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852136, updated on 2-Nov-2024

Summary

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Official Symbol
AGE1
Official Full Name
GTPase-activating protein AGE1
Primary source
SGD:S000002932
Locus tag
YDR524C
See related
AllianceGenome:SGD:S000002932; FungiDB:YDR524C; VEuPathDB:YDR524C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SAT1
Summary
Enables GTPase activator activity and phospholipid binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intra-Golgi vesicle-mediated transport. Located in endosome and trans-Golgi network. Orthologous to several human genes including ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1); ASAP2 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 2); and ASAP3 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See AGE1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1487542..1488990, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Sps2p Neighboring gene putative serine/threonine protein kinase SPS1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A family of Arf effectors defined as suppressors of the loss of Arf function in the yeast Saccharomyces cerevisiae. Zhang CJ, et al. J Biol Chem, 1998 Jul 31. PMID 9677411
  2. Four ARF GAPs in Saccharomyces cerevisiae have both overlapping and distinct functions. Zhang CJ, et al. Yeast, 2003 Mar. PMID 12627398
  3. The yeast Arf GTPase-activating protein Age1 is regulated by phospholipase D for post-Golgi vesicular transport. Benjamin JJ, et al. J Biol Chem, 2011 Feb 18. PMID 21135091, Free PMC Article
  4. Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi. Wong TA, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16126894, Free PMC Article
  5. Requirement of a specific group of sphingolipid-metabolizing enzyme for growth of yeast Saccharomyces cerevisiae under impaired metabolism of glycerophospholipids. Tani M, et al. Mol Microbiol, 2010 Oct. PMID 20979339

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. by direct assessment of Age1 ArfGAP activity that Age1 is regulated by lipid composition and can provide ArfGAP function for post-Golgi transport
    Title: The yeast Arf GTPase-activating protein Age1 is regulated by phospholipase D for post-Golgi vesicular transport.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GTPase-activating protein AGE1
NP_010812.3
  • ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1487542..1488990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180832.3 → NP_010812.3  TPA: GTPase-activating protein AGE1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010812.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTE4, Q04412
    UniProtKB/TrEMBL
    C7GKV5, N1P938
    Conserved Domains (1) summary
    COG5347
    Location:164 → 480
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04412.1

Gene LinkOut

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