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KRE28 Kre28p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852145, updated on 18-Sep-2024

Summary

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Official Symbol
KRE28
Official Full Name
Kre28p
Primary source
SGD:S000002940
Locus tag
YDR532C
See related
AllianceGenome:SGD:S000002940; FungiDB:YDR532C; VEuPathDB:YDR532C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Located in kinetochore. Colocalizes with spindle pole body. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See KRE28 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1499396..1500553, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene bifunctional AP-4-A phosphorylase/ADP sulfurylase Neighboring gene pantothenate kinase Neighboring gene glutathione-independent methylglyoxalase Neighboring gene Fit1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kre28-Spc105 interaction is essential for Spc105 loading at the kinetochore. Roy B, et al. Open Biol, 2022 Jan. PMID 35042402, Free PMC Article
  2. Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. Gatbonton T, et al. PLoS Genet, 2006 Mar. PMID 16552446, Free PMC Article
  3. Cdk1 Phosphorylation of the Dam1 Complex Strengthens Kinetochore-Microtubule Attachments. Gutierrez A, et al. Curr Biol, 2020 Nov 16. PMID 32946748, Free PMC Article
  4. Phosphoregulation of Spc105 by Mps1 and PP1 regulates Bub1 localization to kinetochores. London N, et al. Curr Biol, 2012 May 22. PMID 22521787, Free PMC Article
  5. Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defects. Papsdorf K, et al. BMC Genomics, 2015 Sep 3. PMID 26335097, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kre28-Spc105 interaction is essential for Spc105 loading at the kinetochore.
    Title: Kre28-Spc105 interaction is essential for Spc105 loading at the kinetochore.
  2. the spc105p/kre28p complex has roles in kinetochore-microtubule binding and the spindle assembly checkpoint
    Title: Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole body IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Kre28p
NP_010821.3
  • Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Spc105p; modified by sumoylation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1499396..1500553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180840.3 → NP_010821.3  TPA: Kre28p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010821.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTF3, Q04431, Q6Q537
    UniProtKB/TrEMBL
    N1P947
    Conserved Domains (1) summary
    pfam17097
    Location:1 → 382
    Kre28; Spindle pole body component
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04431.1

Gene LinkOut

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