FDC1 putative phenylacrylic acid decarboxylase FDC1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FDC1
Official Full Name: putative phenylacrylic acid decarboxylase FDC1
Primary source: SGD:S000002947
Locus tag: YDR539W
See related: AllianceGenome:SGD:S000002947; FungiDB:YDR539W; VEuPathDB:YDR539W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables carboxy-lyase activity. Involved in cinnamic acid catabolic process and ferulate metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See FDC1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1512094..1513605)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

substrate scope of ferulic acid decarboxylase (FDC1) from Saccharomyces cerevisiae
Title: Exploring the substrate scope of ferulic acid decarboxylase (FDC1) from Saccharomyces cerevisiae.
PAD1 synthesizes a cofactor required by FDC (ferulic acid decarboxylase) for decarboxylase activity.
Title: Isofunctional enzymes PAD1 and UbiX catalyze formation of a novel cofactor required by ferulic acid decarboxylase and 4-hydroxy-3-polyprenylbenzoic acid decarboxylase.
study presents 3-dimensional structure of FDC1; crystallization with a decarboxylated reaction product identifies a large apolar cavity as the active site and suggests a catalytic mechanism for the nonoxidative decarboxylation reaction of aromatic substrates
Title: Structure and Mechanism of Ferulic Acid Decarboxylase (FDC1) from Saccharomyces cerevisiae.
examination of the contribution of the FDC1 (ferulic acid decarboxylase, YDR539W) gene to the decarboxylation of phenylacrylic acid using gene disruptants and the corresponding transformants in which the disrupted genes were recovered.
Title: PAD1 and FDC1 are essential for the decarboxylation of phenylacrylic acids in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha3077 (e-PCR)
- UniSTS:515638

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables carboxy-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carboxy-lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cinnamic acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cinnamic acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in cinnamic acid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ferulate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ferulate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ferulate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ferulate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative phenylacrylic acid decarboxylase FDC1

NP_010828.1

EC 4.1.1.102

Ferulic acid decarboxylase; involved in the decarboxylation of aromatic carboxylic acids such as phenylacrylic (cinnamic) acid, ferulic acid and coumaric acid and formation of the corresponding vinyl derivatives; overexpression of both Pad1p and Fdc1p increases decarboxylase activity due to the Pad1p-catalyzed formation of a diffusible cofactor required for Fdc1p activity; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm in an HTP study

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1512094..1513605

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180847.1 → NP_010828.1 TPA: putative phenylacrylic acid decarboxylase FDC1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010828.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTF8, Q03034

UniProtKB/TrEMBL

A6ZZC4, B2NII1, B3LFD4, C7GST3, C8Z698, E9P8F1, E9P8F2

Conserved Domains (1) summary

TIGR00148
Location:10 → 463

TIGR00148; UbiD family decarboxylase