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SCS22 phospholipid metabolism-regulating protein SCS22 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852186, updated on 29-Oct-2024

Summary

Official Symbol
SCS22
Official Full Name
phospholipid metabolism-regulating protein SCS22
Primary source
SGD:S000007228
Locus tag
YBL091C-A
See related
AllianceGenome:SGD:S000007228; FungiDB:YBL091C-A; VEuPathDB:YBL091C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable protein-membrane adaptor activity. Involved in endoplasmic reticulum membrane organization; phospholipid biosynthetic process; and regulation of phosphatidylinositol dephosphorylation. Acts upstream of or within reticulophagy. Located in cytosol. Used to study amyotrophic lateral sclerosis type 8. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPA (VAMP associated protein A) and VAPB (VAMP associated protein B and C). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

See SCS22 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_001134.8 (46565..47180, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Rox3p Neighboring gene ribosomal 60S subunit protein L32 Neighboring gene methionine aminopeptidase Neighboring gene mitochondrial 37S ribosomal protein MRP21

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
phospholipid metabolism-regulating protein SCS22
NP_009461.2
  • Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect the ER and plasma membrane (PM); regulates PM PI4P levels by controlling access of the Sac1p phosphatase to its substrate, PI4P; human VAP homolog; similar to D. melanogaster inturned protein; SWAT-GFP and mCherry fusion proteins localize to the cytosol; SCS22 has a paralog, SCS2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    46565..47180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184321.1NP_009461.2  TPA: phospholipid metabolism-regulating protein SCS22 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009461.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPR2, Q6Q595
    UniProtKB/TrEMBL
    B3LNM3, C8Z3V3, N1PAR6
    Conserved Domains (1) summary
    pfam00635
    Location:1107
    Motile_Sperm; MSP (Major sperm protein) domain