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PET112 glutamyl-tRNA(Gln) amidotransferase subunit PET112 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852198, updated on 2-Nov-2024

Summary

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Official Symbol
PET112
Official Full Name
glutamyl-tRNA(Gln) amidotransferase subunit PET112
Primary source
SGD:S000000176
Locus tag
YBL080C
See related
AllianceGenome:SGD:S000000176; FungiDB:YBL080C; VEuPathDB:YBL080C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidotransferase complex. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 41. Orthologous to human GATB (glutamyl-tRNA amidotransferase subunit B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PET112 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (73070..74695, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase Neighboring gene uncharacterized protein Neighboring gene Nup170p Neighboring gene ubiquitin-like protein ATG8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PET112, a Saccharomyces cerevisiae nuclear gene required to maintain rho+ mitochondrial DNA. Mulero JJ, et al. Curr Genet, 1994 Apr. PMID 8082172
  2. A nuclear genetic lesion affecting Saccharomyces cerevisiae mitochondrial translation is complemented by a homologous Bacillus gene. Kim SI, et al. J Bacteriol, 1997 Sep. PMID 9287027, Free PMC Article
  3. Characterization of Gtf1p, the connector subunit of yeast mitochondrial tRNA-dependent amidotransferase. Barros MH, et al. J Biol Chem, 2011 Sep 23. PMID 21799017, Free PMC Article
  4. Her2p molecular modeling, mutant analysis and intramitochondrial localization. Ferreira-Júnior JR, et al. Fungal Genet Biol, 2013 Nov. PMID 23850602
  5. Pathogenic variants in glutamyl-tRNA(Gln) amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder. Friederich MW, et al. Nat Commun, 2018 Oct 3. PMID 30283131, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The crystal structure of yeast mitochondrial GatFAB complex.
    Title: Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables carbon-nitrogen ligase activity, with glutamine as amido-N-donor IEA
Inferred from Electronic Annotation
more info
  
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutaminyl-tRNAGln biosynthesis via transamidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutaminyl-tRNAGln biosynthesis via transamidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutaminyl-tRNAGln biosynthesis via transamidation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of glutamyl-tRNA(Gln) amidotransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glutamyl-tRNA(Gln) amidotransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of glutamyl-tRNA(Gln) amidotransferase complex IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamyl-tRNA(Gln) amidotransferase subunit PET112
NP_009473.2
  • Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    73070..74695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178320.2 → NP_009473.2  TPA: glutamyl-tRNA(Gln) amidotransferase subunit PET112 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009473.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZKM2, D6VPS3, P33893
    UniProtKB/TrEMBL
    G2W8T2, N1P9I4
    Conserved Domains (1) summary
    TIGR00133
    Location:24 → 538
    gatB; aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33893.3

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