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PRS4 ribose phosphate diphosphokinase subunit PRS4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852211, updated on 28-Oct-2024

Summary

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Official Symbol
PRS4
Official Full Name
ribose phosphate diphosphokinase subunit PRS4
Primary source
SGD:S000000164
Locus tag
YBL068W
See related
AllianceGenome:SGD:S000000164; FungiDB:YBL068W; VEuPathDB:YBL068W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process. Located in cytoplasm. Part of ribose phosphate diphosphokinase complex. Used to study diabetes insipidus and fundus dystrophy. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1); PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1); and PRPS2 (phosphoribosyl pyrophosphate synthetase 2). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See PRS4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (92414..93394)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Kti11p Neighboring gene Ast1p Neighboring gene ubiquitin-specific protease UBP13 Neighboring gene Sef1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Prenatal growth restriction, retinal dystrophy, diabetes insipidus and white matter disease: expanding the spectrum of PRPS1-related disorders. Al-Maawali A, et al. Eur J Hum Genet, 2015 Mar. PMID 24961627, Free PMC Article
  2. Impaired proteasome function rescues thermosensitivity of yeast cells lacking the coatomer subunit epsilon-COP. Kimata Y, et al. J Biol Chem, 2000 Apr 7. PMID 10744762
  3. Phosphoribosylpyrophosphate synthetase (PRS): a new gene family in Saccharomyces cerevisiae. Carter AT, et al. Yeast, 1994 Aug. PMID 7992503
  4. PRS1 is a key member of the gene family encoding phosphoribosylpyrophosphate synthetase in Saccharomyces cerevisiae. Carter AT, et al. Mol Gen Genet, 1997 Mar 26. PMID 9108276
  5. PRS5, the fifth member of the phosphoribosyl pyrophosphate synthetase gene family in Saccharomyces cerevisiae, is essential for cell viability in the absence of either PRS1 or PRS3. Hernando Y, et al. J Bacteriol, 1998 Dec. PMID 9829955, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ribose phosphate diphosphokinase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ribose phosphate diphosphokinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribonucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of ribose phosphate diphosphokinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribose phosphate diphosphokinase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribose phosphate diphosphokinase subunit PRS4
NP_009485.3
  • 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    92414..93394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178308.2 → NP_009485.3  TPA: ribose phosphate diphosphokinase subunit PRS4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009485.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPT3, P38063, Q9HGQ6
    UniProtKB/TrEMBL
    A6ZKN2, B3LNK2, C7GN99, G2W8U2, N1P9M4
    Conserved Domains (1) summary
    COG0462
    Location:11 → 322
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38063.3

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