U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SKT5 Skt5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852218, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
SKT5
Official Full Name
Skt5p
Primary source
SGD:S000000157
Locus tag
YBL061C
See related
AllianceGenome:SGD:S000000157; FungiDB:YBL061C; VEuPathDB:YBL061C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CAL2; CHS4; CSD4
Summary
Enables enzyme activator activity. Involved in chitin biosynthetic process. Located in cellular bud neck and incipient cellular bud site. Orthologous to human DELE1 (DAP3 binding cell death enhancer 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SKT5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (105316..107406, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene thioredoxin peroxidase PRX1 Neighboring gene Kip1p Neighboring gene Arf family guanine nucleotide exchange factor YEL1 Neighboring gene Cmc2p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A mutant allele skt5 affecting protoplast regeneration and killer toxin resistance has double mutations in its wild-type structural gene in Saccharomyces cerevisiae. Kawamoto S, et al. Biosci Biotechnol Biochem, 1993 Aug. PMID 7764021
  2. Characterization of CHS4 (CAL2), a gene of Saccharomyces cerevisiae involved in chitin biosynthesis and allelic to SKT5 and CSD4. Trilla JA, et al. Yeast, 1997 Jul. PMID 9234668
  3. The Candida albicans CHS4 gene complements a Saccharomyces cerevisiae skt5/chs4 mutation and is involved in chitin biosynthesis. Sudoh M, et al. Microbiology (Reading), 1999 Jul. PMID 10439400
  4. Prenylation of Saccharomyces cerevisiae Chs4p Affects Chitin Synthase III activity and chitin chain length. Grabińska KA, et al. Eukaryot Cell, 2007 Feb. PMID 17142567, Free PMC Article
  5. Control of chitin synthesis through Shc1p, a functional homologue of Chs4p specifically induced during sporulation. Sanz M, et al. Mol Microbiol, 2002 Mar. PMID 11918806

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transient septin sumoylation steers a Fir1-Skt5 protein complex between the split septin ring.
    Title: Transient septin sumoylation steers a Fir1-Skt5 protein complex between the split septin ring.
  2. Hof1 binds to the Sel1-like repeats (SLRs) of Chs4 via its F-BAR domain and inhibits Chs3-mediated chitin synthesis during cytokinesis. In addition, Hof1 is required for rapid accumulation as well as efficient removal of Chs4 at the division site.
    Title: Hof1 and Chs4 Interact via F-BAR Domain and Sel1-like Repeats to Control Extracellular Matrix Deposition during Cytokinesis.
  3. Results suggest that Chs4p promotes Chs3p translocation into the plasma membrane in a stable and active form, and that proper chitin synthase III turnover is maintained through the endocytic internalization of Chs3p.
    Title: Chitin synthase III requires Chs4p-dependent translocation of Chs3p into the plasma membrane.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chitin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Skt5p
NP_009492.1
  • Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    105316..107406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178301.1 → NP_009492.1  TPA: Skt5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009492.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPT8, P34226, Q02215
    UniProtKB/TrEMBL
    A6ZKN7, B3LNJ7
    Conserved Domains (3) summary
    smart00671
    Location:499 → 534
    SEL1; Sel1-like repeats
    COG0790
    Location:245 → 505
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:407 → 436
    SLR; SLR repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34226.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools