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YEL1 Arf family guanine nucleotide exchange factor YEL1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852219, updated on 2-Nov-2024

Summary

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Official Symbol
YEL1
Official Full Name
Arf family guanine nucleotide exchange factor YEL1
Primary source
SGD:S000000156
Locus tag
YBL060W
See related
AllianceGenome:SGD:S000000156; FungiDB:YBL060W; VEuPathDB:YBL060W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in actin cortical patch localization; positive regulation of phosphatidylinositol biosynthetic process; and protein localization. Located in cellular bud neck and cellular bud tip. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See YEL1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (107932..109995)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Kip1p Neighboring gene Skt5p Neighboring gene Cmc2p Neighboring gene Iai11p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a guanine nucleotide exchange factor for Arf3, the yeast orthologue of mammalian Arf6. Gillingham AK, et al. PLoS One, 2007 Sep 5. PMID 17786213, Free PMC Article
  2. Afi1p functions as an Arf3p polarization-specific docking factor for development of polarity. Tsai PC, et al. J Biol Chem, 2008 Jun 13. PMID 18397879
  3. Arf3p GTPase is a key regulator of Bud2p activation for invasive growth in Saccharomyces cerevisiae. Hsu JW, et al. Mol Biol Cell, 2013 Aug. PMID 23783029, Free PMC Article
  4. Snf1/AMP-activated protein kinase activates Arf3p to promote invasive yeast growth via a non-canonical GEF domain. Hsu JW, et al. Nat Commun, 2015 Jul 22. PMID 26198097, Free PMC Article
  5. Yeast Arf3p modulates plasma membrane PtdIns(4,5)P2 levels to facilitate endocytosis. Smaczynska-de Rooij II, et al. Traffic, 2008 Apr. PMID 18208507, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cortical patch localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Arf family guanine nucleotide exchange factor YEL1
NP_009493.1
  • Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    107932..109995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178300.1 → NP_009493.1  TPA: Arf family guanine nucleotide exchange factor YEL1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009493.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZKN8, C8Z3N7, D6VPT9, P34225
    UniProtKB/TrEMBL
    G2W8U8
    Conserved Domains (1) summary
    COG5307
    Location:1 → 687
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34225.1

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