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PTC3 type 2C protein phosphatase PTC3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852224, updated on 28-Oct-2024

Summary

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Official Symbol
PTC3
Official Full Name
type 2C protein phosphatase PTC3
Primary source
SGD:S000000152
Locus tag
YBL056W
See related
AllianceGenome:SGD:S000000152; FungiDB:YBL056W; VEuPathDB:YBL056W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein serine/threonine phosphatase activity. Involved in regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nucleus. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See PTC3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (113762..115168)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene protein phosphatase regulator SHP1 Neighboring gene aminoacyl-tRNA hydrolase Neighboring gene 3'-5'-exodeoxyribonuclease Neighboring gene Tod6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein phosphatases pph3, ptc2, and ptc3 play redundant roles in DNA double-strand break repair by homologous recombination. Kim JA, et al. Mol Cell Biol, 2011 Feb. PMID 21135129, Free PMC Article
  2. Role of Ptc2 type 2C Ser/Thr phosphatase in yeast high-osmolarity glycerol pathway inactivation. Young C, et al. Eukaryot Cell, 2002 Dec. PMID 12477803, Free PMC Article
  3. Distinct phosphatases mediate the deactivation of the DNA damage checkpoint kinase Rad53. Travesa A, et al. J Biol Chem, 2008 Jun 20. PMID 18441009
  4. A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Maeda T, et al. Nature, 1994 May 19. PMID 8183345
  5. Mutations in a protein tyrosine phosphatase gene (PTP2) and a protein serine/threonine phosphatase gene (PTC1) cause a synthetic growth defect in Saccharomyces cerevisiae. Maeda T, et al. Mol Cell Biol, 1993 Sep. PMID 8395005, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cation binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
type 2C protein phosphatase PTC3
NP_009497.2
  • Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    113762..115168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178296.2 → NP_009497.2  TPA: type 2C protein phosphatase PTC3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009497.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPU4, P34221, Q92330
    UniProtKB/TrEMBL
    A6ZKP3, B3LNJ2, B5VDS9, C7GNA9, G2W8V3, N1P7C7
    Conserved Domains (1) summary
    pfam00481
    Location:23 → 280
    PP2C; Protein phosphatase 2C
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34221.4

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